Journal ArticleDOI
Bioactive Limonoid Constituents of Munronia henryi.
Ying Yan,Ying Yan,Jian-Xin Zhang,Tao Huang,Xin-Ying Mao,Wei Gu,Hong-Ping He,Ying-Tong Di,Shun-Lin Li,Duo-Zhi Chen,Yu Zhang,Xiao-Jiang Hao +11 more
TLDR
Fourteen new limonoid, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi and showed significant anti-tobacco mosaic virus activity and in vitro cytotoxicity against the human cancer cell lines.Abstract:
Fourteen new limonoids, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry, and the structure of 8 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom. All compounds were evaluated for their anti-tobacco mosaic virus (TMV) activity and in vitro cytotoxicity against the human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Among them, compounds 2, 8, 9, 10, 11, 12, 18, and 20 showed significant anti-TMV activity, with IC50 values in the range 19.6-44.4 mu g/mL. Compounds 1 and 18 exhibited cytotoxic effects for all five cancer cell lines, with IC50 values between 0.4 and 4.8 mu M.read more
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Recent progress in the chemistry and biology of limonoids
Yuanyuan Zhang,Hui Xu +1 more
TL;DR: This review covers the isolation and structure determination of limonoids reported during 2014–2016 (with 363 new compounds in 68 papers), together with the relevant biological activities and source organisms.
Journal ArticleDOI
Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids from Trichilia connaroides.
Fa-Liang An,Jun Luo,Rui-Jun Li,Jian-Guang Luo,Xiao-Bing Wang,Ming-Hua Yang,Lei Yang,Hequan Yao,Hongbin Sun,Yi-Jun Chen,Ling-Yi Kong +10 more
TL;DR: Spirotrichilins A and B, two novel limonoids with an unprecedented spiro[cyclopenta[b]furan-2,1'-cyclopentan] ring system in A/B/C rings, were isolated from the fruits of trichilia connaroides and their planar structures and absolute configurations were established.
Journal ArticleDOI
Advanced natural products chemistry research in China between 2015 and 2017.
TL;DR: This review intensively focus on the advances in research of natural products (NPs) discovery carried out by domestic scholars in China from 2015 through 2017, mainly organized according to their structural classes and novelties.
Journal ArticleDOI
Research progress of meliaceous limonoids from 2011 to 2021.
TL;DR: A recent review summarizes the recent research progress in the discovery of new structures, medicinal and agricultural bioactivities, and chem/biosynthesis of limonoids from the plants of the Meliaceae family during the past decade as discussed by the authors .
Journal ArticleDOI
Limonoids from Munronia henryi and their anti-tobacco mosaic virus activity.
Ying Yan,Chun-Mao Yuan,Ying-Tong Di,Tao Huang,Yi-Min Fan,Yuan Ma,Jian-Xin Zhang,Xiao-Jiang Hao +7 more
TL;DR: Five new compounds, including three limonoid, one diterpenoid, and one phytosterol, along with four known limonoids, were isolated from the ethanolic extracts of whole plants of Munronia henryi, and their structures were elucidated by extensive spectroscopic analysis.
References
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Journal ArticleDOI
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
Anne Monks,Dominic A. Scudiero,Philip Skehan,Robert H. Shoemaker,Kenneth D. Paull,David T. Vistica,Curtis Hose,John Langley,Paul Cronise,Anne Vaigro-Wolff,Marcia Gray-Goodrich,H. D. Campbell,Joseph G. Mayo,Michael R. Boyd +13 more
TL;DR: A pilot-scale, in vitro, anticancer drug screen utilizing a panel of 60 human tumor cell lines organized into subpanels representing leukemia, melanoma, and cancers of the lung, colon, kidney, ovary, and central nervous system is described.
Journal Article
A simple technique for purification of tobacco mosaic virus in large quantities.
Gooding Gv,Hebert Tt +1 more
Journal ArticleDOI
Meliaceous limonoids: chemistry and biological activities.
Qin-Gang Tan,Xiao-Dong Luo +1 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
Journal ArticleDOI
Synthesis and Antiviral Activities of Phenanthroindolizidine Alkaloids and Their Derivatives
TL;DR: These findings demonstrate that these phenanthroindolizidine alkaloids and their salt derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.