Xinming Wang

TL;DR: A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.

TL;DR: This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.

TL;DR: Wang et al. as discussed by the authors found the pathogenicity of 2019-nCoV in hACE2 mice, and the Koch's postulates were fulfilled as well, and they may facilitate the development of therapeutics and vaccines against 2019 nCoV.

TL;DR: Investigation of the durability and functionality of the humoral and T-cell response to the original SARS-CoV-2 strain and variants in recovered patients 12 months after infection found neutralising antibodies remained stable 6 and 12 years after initial infection in most individuals younger than 60 years.

TL;DR: The pathogenicity of Sars-CoV-2 in hACE2 mice was clarified and the Koch’s postulates were fulfilled, and the mouse model may facilitate the development of therapeutics and vaccines against SARS-Cov-2.