Y
Yanchun Peng
Researcher at University of Oxford
Publications - 54
Citations - 3060
Yanchun Peng is an academic researcher from University of Oxford. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 13, co-authored 41 publications receiving 1819 citations. Previous affiliations of Yanchun Peng include Peking Union Medical College & Medical Research Council.
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Journal ArticleDOI
Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Yanchun Peng,Alexander J. Mentzer,G Liu,G Liu,X Yao,Z Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,C Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,Guido C. Paesen,Jonathan M. Grimes,Alfred A. Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,B Wang,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,P Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,J K Baillie,Shona C Moore,Openshaw Pjm.,M A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,G Kerr,Philip J. R. Goulder,T Lockett,R Levin,Y Zhang,Y Zhang,R Jing,Ho L-P.,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Gavin R. Screaton,Juthathip Mongkolsapaya,Andrew J. McMichael,Julian C. Knight,Graham S. Ogg,Tao Dong +67 more
TL;DR: The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
Journal ArticleDOI
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
Lee Ly-H.,Ha Dla.,Cameron P. Simmons,Cameron P. Simmons,de Jong,Chau Nvv.,R Schumacher,Yanchun Peng,Andrew J. McMichael,Jeremy Farrar,Geoffrey L. Smith,Townsend Arm.,B A Askonas,Sarah Rowland-Jones,Tao Dong +14 more
TL;DR: Ex vivo analysis of cross-reactive CD4+ and CD8+ memory T cell responses to overlapping peptides spanning the full proteome of influenza A and influenza A in healthy individuals from the United Kingdom and Viet Nam shows that vaccine formulas inducing heterosubtypic T cell-mediated immunity may confer broad protection against avian and human influenza A viruses.
Journal ArticleDOI
Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease.
Yan Zhao,Ling Qin,P Zhang,Kang Li,Lianchun Liang,Jianping Sun,Bin Xu,Yanchao Dai,Xuemei Li,Chunpan Zhang,Yanchun Peng,Yingmei Feng,A Li,Zhongjie Hu,Haiping Xiang,Graham S. Ogg,Graham S. Ogg,Ho L-P.,Ho L-P.,A J McMichael,Ronghua Jin,Julian C. Knight,Tao Dong,Tao Dong,Yonghong Zhang +24 more
TL;DR: The chemokine RANTES(CCL5) was significantly elevated, from an early stage of the infection, in patients with mild but not severe disease, and early production of inhibitory mediators including IL-10 and IL-1RA were significantly associated with disease severity, suggesting early intervention to increase expression of CCL5 may prevent patients from developing severe illness.
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The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Wanwisa Dejnirattisai,D. Zhou,Helen M. Ginn,Helen M. E. Duyvesteyn,Piyada Supasa,James Brett Case,Yuguang Zhao,Thomas S. Walter,Alexander J. Mentzer,Chang Liu,Beibei Wang,Guido C. Paesen,J Slon-Campos,Cesar Lopez-Camacho,Natasha M. Kafai,Adam L. Bailey,Rita E. Chen,Baoling Ying,Craig Thompson,Jai S Bolton,Alex Fyfe,Sunetra Gupta,Tiong Kit Tan,Javier Gilbert-Jaramillo,William James,Michael L. Knight,Miles W. Carroll,Donal T. Skelly,Christina Dold,Yanchun Peng,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Paul Klenerman,Nigel J. Temperton,David R. Hall,Mark A. Williams,Neil G. Paterson,Felicity K.R. Bertram,C. Alistair Siebert,Daniel K. Clare,Andy G. Howe,Julika Radecke,Yun Song,Alain Townsend,Kuan-Ying A. Huang,Elizabeth E. Fry,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Michael S. Diamond,Jingshan Ren,David I. Stuart,Gavin R. Screaton +53 more
TL;DR: In this paper, the authors identify 377 human monoclonal antibodies (mAbs) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (RBD) and devise a competition data-driven method to map RBD binding sites.
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Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
Yonghong Zhang,Yan Zhao,Ning Li,Yanchun Peng,Eleni Giannoulatou,Ronghua Jin,Hui-ping Yan,Hao Wu,Jinhua Liu,Ning Liu,Dayan Wang,Yuelong Shu,Ling-Pei Ho,Paul Kellam,Paul Kellam,Andrew J. McMichael,Tao Dong,Tao Dong +17 more
TL;DR: It is reported that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection, and its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied.