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Xiushan Wu
Researcher at Hunan Normal University
Publications - 114
Citations - 3088
Xiushan Wu is an academic researcher from Hunan Normal University. The author has contributed to research in topics: Zinc finger & Gene. The author has an hindex of 27, co-authored 103 publications receiving 2832 citations. Previous affiliations of Xiushan Wu include East China Normal University & University of Michigan.
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Journal ArticleDOI
Heart development in Drosophila requires the segment polarity gene wingless.
TL;DR: It is demonstrated that the gene wingless (wg), which is known to specify segmental polarity and neuroblast identity in Drosophila, has a novel role in mesoderm development: wg function is specifically required for heart development.
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Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia.
Yie Liu,Martin Corcoran,Omid Rasool,Ganka Ivanova,Rachel E. Ibbotson,Dan Grandér,Arati Iyengar,Anna Baranova,Vladimir I. Kashuba,Mats Merup,Xiushan Wu,Anne Gardiner,Roman Müllenbach,Andrew B. Poltaraus,Anna Linda Hultström,Gunnar Juliusson,R. Chapman,Mary Tiller,Finbarr E. Cotter,Gösta Gahrton,N. K. Yankovsky,Eugene R. Zabarovsky,Stefan Einhorn,David Oscier +23 more
TL;DR: It is concluded that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
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The wingless signaling pathway is directly involved in Drosophila heart development.
TL;DR: It is shown that wg is epistatic to hedgehog, another secreted segmentation gene product, in its requirement for heart formation, and evidence show that downstream of wg in the signal transduction cascade, dishevelled and armadillo are mediating the cardiogenic Wg signal.
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Regulation of bone formation and remodeling by G-protein-coupled receptor 48
Jian Luo,Jian Luo,Jian Luo,Wei Zhou,Xin Zhou,Dali Li,Dali Li,Jinsheng Weng,Zhengfang Yi,Sung Gook Cho,Chenghai Li,Tingfang Yi,Xiushan Wu,Xiaoying Li,Benoit de Crombrugghe,Magnus Höök,Mingyao Liu,Mingyao Liu +17 more
TL;DR: Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway and significantly downregulates the expression levels of Atf4 target genes/proteins, such as osteocalcin, bone sialoprotein and collagen.
Journal ArticleDOI
13q deletions in lymphoid malignancies
Yie Liu,Monica Hermanson,Dan Grandér,Mats Merup,Xiushan Wu,Mats Heyman,Omid Rasool,Gunnar Juliusson,Gösta Gahrton,Ruth Detlofsson,Natalia Nikiforova,Charles H.C.M. Buys,Stefan Söderhäll,N. K. Yankovsky,Eugene R. Zabarovsky,Stefan Einhorn +15 more
TL;DR: The data suggest that 13q deletions are common in lymphoid neoplasms, and that deletion of a candidate tumor suppressor gene(s) in the vicinity of the D13S319 marker is a tumorigenic event in these diseases.