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Xuejun Jiang
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 23
Citations - 7141
Xuejun Jiang is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Apoptosome & Guanine nucleotide exchange factor. The author has an hindex of 14, co-authored 23 publications receiving 6759 citations. Previous affiliations of Xuejun Jiang include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Cytochrome C-Mediated Apoptosis
Xuejun Jiang,Xiaodong Wang +1 more
TL;DR: Recent progress in understanding the biochemical mechanisms and regulation of the caspase activation pathway, the roles of the pathway in physiology and disease, and their potential therapeutic values are focused on.
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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.
Devrim Acehan,Xuejun Jiang,David Gene Morgan,David Gene Morgan,John E. Heuser,Xiaodong Wang,Christopher W. Akey +6 more
TL;DR: Molecular modeling was used to identify the caspase recruitment and WD40 domains within the apoptosome and to infer likely positions of the CED4 homology motif and cytochrome c, suggesting a plausible role for cy tochrome c in apoptosomes assembly.
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p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
Tohru Kozasa,Xuejun Jiang,Matthew J. Hart,Pamela M. Sternweis,William D. Singer,Alfred G. Gilman,Gideon Bollag,Paul C. Sternweis +7 more
TL;DR: Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the α subunits of certain heterotrimeric guanine nucleotide–binding proteins (G proteins).
Journal ArticleDOI
Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα13
Matthew J. Hart,Xuejun Jiang,Tohru Kozasa,William Roscoe,William D. Singer,Alfred G. Gilman,Paul C. Sternweis,Gideon Bollag +7 more
TL;DR: The GTPase activities of two G protein alpha subunits, Galpha12 and Galpha13, are stimulated by the Rho guanine nucleotide exchange factor p115 RhoGEF, which can directly link heterotrimeric G proteinalpha subunits to regulation of Rho.
Journal ArticleDOI
Ubiquitination regulates PTEN nuclear import and tumor suppression
Lloyd C. Trotman,Xinjiang Wang,Andrea Alimonti,Zhenbang Chen,Julie Teruya-Feldstein,Haijuan Yang,Nikola P. Pavletich,Brett S. Carver,Carlos Cordon-Cardo,Hediye Erdjument-Bromage,Paul Tempst,Sung Gil Chi,Hyo Jong Kim,Tom Misteli,Xuejun Jiang,Pier Paolo Pandolfi +15 more
TL;DR: It is shown that nuclear PTEN is essential for tumor suppression and that PTEN nuclear import is mediated by its monoubiquitination, and how a discrete molecular mechanism dictates tumor progression by differentiating between degradation and protection ofPTEN is demonstrated.