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Ya Tsz A. Chim
Researcher at University of Nottingham
Publications - 4
Citations - 275
Ya Tsz A. Chim is an academic researcher from University of Nottingham. The author has contributed to research in topics: DNA condensation & Force spectroscopy. The author has an hindex of 4, co-authored 4 publications receiving 266 citations.
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Journal ArticleDOI
Preferential liver gene expression with polypropylenimine dendrimers.
Andreas G. Schätzlein,Bernd H. Zinselmeyer,Bernd H. Zinselmeyer,Adurrahim Elouzi,Christine Dufès,Ya Tsz A. Chim,Clive J. Roberts,Martyn C. Davies,Avril Anstruther Munro,Alexander I. Gray,Ijeoma F. Uchegbu +10 more
TL;DR: It is concluded that the polypropylenimine dendrimers are promising gene delivery systems which may be used to target the liver and avoid the lung and also that molecular modifications conferring colloidal stability on gene delivery formulations have a profound effect on their tolerability on intravenous administration.
Journal ArticleDOI
Structural study of DNA condensation induced by novel phosphorylcholine-based copolymers for gene delivery and relevance to DNA protection.
Ya Tsz A. Chim,Jenny K.W. Lam,Y Ma,S P Armes,Andrew L. Lewis,Clive J. Roberts,Snjezana Stolnik,Saul J. B. Tendler,Martyn C. Davies +8 more
TL;DR: Assessment of the morphologies of DNA complexes obtained using the diblock copolymer series DMA(x)MPC30 (where the mean degree of polymerization of the MPC block was fixed at 30 and the DMA block length was systematically varied) using transmission electron microscopy and liquid atomic force microscopy indicates more compact complex morphologies (more efficient condensation) as the length of the cationic D MA block increases.
Journal ArticleDOI
Dimerization and DNA‐dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA
Sarah Cosgriff,Kiran Chintakayala,Ya Tsz A. Chim,Xinyong Chen,Stephanie Allen,Andrew L. Lovering,David C. Grainger +6 more
TL;DR: Using a combination of genetics, biochemistry, structural modelling and single‐molecule atomic force microscopy, data show that CbpA dimerization is driven by a hydrophobic surface comprising amino acid side chains W287 and L290 located on the same side of an α helix close to the C‐terminus of CBPA.
Journal Article
Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy
James S. Ellis,Stephanie Allen,Ya Tsz A. Chim,Clive J. Roberts,Saul J. B. Tendler,Martyn C. Davies +5 more
TL;DR: This review explores the most common modes of AFM operation including imaging (contact and tapping mode) and force spectroscopy and the application of these modes to biopolymer characterisation will be discussed, with an emphasis on key studies.