Yair Field

TL;DR: This work isolated nucleosome-bound sequences at high resolution from yeast and used these sequences in a new computational approach to construct and validate experimentally a nucleosom–DNA interaction model, and to predict the genome-wide organization of nucleosomes.

TL;DR: The results indicate that the intrinsic DNA sequence preferences of nucleosomes have a central role in determining the organization ofucleosomes in vivo.

TL;DR: A genome-wide map of ∼380,000 yeast nucleosomes is used and it is found that Poly(dA:dT) tracts are an important component of these nucleosome positioning signals and that their nucleosom-disfavoring action results in large nucleosite depletion over them and over their flanking regions and enhances the accessibility of transcription factors to their cognate sites.

TL;DR: The generation of anti-ubH2B monoclonal antibodies using a branched peptide as immunogen is reported, suggesting that H2B ubiquitination is intimately linked with global transcriptional elongation in mammalian cells.

TL;DR: The singleton density score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences, is introduced, suggesting that polygenic adaptation has played a pervasive role in shaping genotypic and phenotypic variation in modern humans.