scispace - formally typeset
K

Kyle J. Gaulton

Researcher at University of California, San Diego

Publications -  106
Citations -  10560

Kyle J. Gaulton is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 40, co-authored 86 publications receiving 8397 citations. Previous affiliations of Kyle J. Gaulton include Stanford University & Broad Institute.

Papers
More filters
Journal ArticleDOI

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Anubha Mahajan, +395 more
- 01 Mar 2014 - 
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Journal ArticleDOI

The genetic architecture of type 2 diabetes

Christian Fuchsberger, +349 more
- 11 Jul 2016 - 
TL;DR: In this paper, the authors performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing for 12,940 individuals from five ancestry groups.

The genetic architecture of type 2 diabetes

Christian Fuchsberger, +300 more
TL;DR: Large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes, but most fell within regions previously identified by genome-wide association studies.
Journal ArticleDOI

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Robert A. Scott, +216 more
- 01 Nov 2017 - 
TL;DR: This article conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel.
Journal ArticleDOI

A map of open chromatin in human pancreatic islets

Kyle J. Gaulton, +14 more
- 01 Mar 2010 - 
TL;DR: It is found that human islet samples heterozygous for rs7903146 showed allelic imbalance in islet FAIRE signals and that the variant alters enhancer activity, indicating that genetic variation at this locus acts in cis with local chromatin and regulatory changes.