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Yaira Z. Nunez
Researcher at Yale University
Publications - 26
Citations - 683
Yaira Z. Nunez is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 9, co-authored 20 publications receiving 348 citations. Previous affiliations of Yaira Z. Nunez include Boston University & Veterans Health Administration.
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Journal ArticleDOI
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
Daniel F. Levey,Daniel F. Levey,Murray B. Stein,Murray B. Stein,Frank R. Wendt,Frank R. Wendt,Gita A. Pathak,Gita A. Pathak,Hang Zhou,Hang Zhou,Mihaela Aslan,Rachel Quaden,Kelly M. Harrington,Kelly M. Harrington,Yaira Z. Nunez,Yaira Z. Nunez,Cassie Overstreet,Cassie Overstreet,Krishnan Radhakrishnan,Gerard Sanacora,Gerard Sanacora,Andrew M. McIntosh,Jingchunzi Shi,Suyash Shringarpure,Million Veteran Program,Million Veteran Program,John Concato,Renato Polimanti,Renato Polimanti,Joel Gelernter,Joel Gelernter +30 more
TL;DR: In this article, a large meta-analysis of depression using data from the Million Veteran Program, 23andMe, UK Biobank and FinnGen, including individuals of European ancestry (n = 1,154,267; 340,591 cases) and African ancestry(n = 59,600; 25,843 cases).
Journal ArticleDOI
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Hang Zhou,Hang Zhou,Christopher T Rentsch,Christopher T Rentsch,Christopher T Rentsch,Zhongshan Cheng,Zhongshan Cheng,Rachel L. Kember,Rachel L. Kember,Yaira Z. Nunez,Yaira Z. Nunez,Richard Sherva,Janet P. Tate,Janet P. Tate,Cecilia Dao,Cecilia Dao,Ke Xu,Ke Xu,Renato Polimanti,Renato Polimanti,Lindsay A. Farrer,Amy C. Justice,Amy C. Justice,Henry R. Kranzler,Henry R. Kranzler,Joel Gelernter +25 more
TL;DR: A genome-wide meta-analysis identified a significant association of OUD with an OPRM1 variant, which was replicated in 2 independent samples and revealed associated pleiotropic characteristics.
Journal ArticleDOI
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1
Andrew H. Smith,Kevin P. Jensen,Jin Li,Yaira Z. Nunez,Lindsay A. Farrer,Hakon Hakonarson,Hakon Hakonarson,Scott D. Cook-Sather,Henry R. Kranzler,Joel Gelernter +9 more
TL;DR: The present results in AAs indicate that genetic variants influencing opioid sensitivity across different clinical settings could contribute to precision pharmacotherapy for pain and addiction.
Journal ArticleDOI
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression
Hang Zhou,Renato Polimanti,Bao-Zhu Yang,Bao-Zhu Yang,Qian Wang,Shizhong Han,Richard Sherva,Yaira Z. Nunez,Yaira Z. Nunez,Hongyu Zhao,Lindsay A. Farrer,Henry R. Kranzler,Henry R. Kranzler,Joel Gelernter +13 more
TL;DR: This genome-wide association study analyzed criterion counts of comorbid AD and MD in African American and European American data sets collected as part of the Yale-Penn study of the genetics of drug and alcohol dependence to determine whether polygenic risk alleles are shared with neuropsychiatric traits or subcortical brain volumes.
Journal ArticleDOI
Genetic associations with suicide attempt severity and genetic overlap with major depression
Daniel F. Levey,Renato Polimanti,Renato Polimanti,Zhongshan Cheng,Zhongshan Cheng,Hang Zhou,Hang Zhou,Yaira Z. Nunez,Yaira Z. Nunez,Sonia Jain,Feng He,Xiaoying Sun,Robert J. Ursano,Ronald C. Kessler,Jordan W. Smoller,Murray B. Stein,Murray B. Stein,Henry R. Kranzler,Joel Gelernter +18 more
TL;DR: A genome-wide association study of severity of suicide attempts to investigate genetic influences and identified GWS associations near genes involved in anaerobic energy production, circadian clock regulation, and catabolism of tyrosine.