K
Krishnan Radhakrishnan
Researcher at University of Kentucky
Publications - 22
Citations - 925
Krishnan Radhakrishnan is an academic researcher from University of Kentucky. The author has contributed to research in topics: Bipolar disorder & Veterans Affairs. The author has an hindex of 12, co-authored 18 publications receiving 567 citations. Previous affiliations of Krishnan Radhakrishnan include University of New Mexico & Substance Abuse and Mental Health Services Administration.
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Journal ArticleDOI
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining
Sheema Fnu,Elizabeth A. Williamson,Leyma P. De Haro,Mark A. Brenneman,Justin Wray,Montaser Shaheen,Krishnan Radhakrishnan,Suk Hee Lee,Jac A. Nickoloff,Robert Hromas +9 more
TL;DR: A histone methylation event that enhances DNA DSB repair by nonhomologous end-joining (NHEJ) is defined.
Journal ArticleDOI
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
Daniel F. Levey,Daniel F. Levey,Murray B. Stein,Murray B. Stein,Frank R. Wendt,Frank R. Wendt,Gita A. Pathak,Gita A. Pathak,Hang Zhou,Hang Zhou,Mihaela Aslan,Rachel Quaden,Kelly M. Harrington,Kelly M. Harrington,Yaira Z. Nunez,Yaira Z. Nunez,Cassie Overstreet,Cassie Overstreet,Krishnan Radhakrishnan,Gerard Sanacora,Gerard Sanacora,Andrew M. McIntosh,Jingchunzi Shi,Suyash Shringarpure,Million Veteran Program,Million Veteran Program,John Concato,Renato Polimanti,Renato Polimanti,Joel Gelernter,Joel Gelernter +30 more
TL;DR: In this article, a large meta-analysis of depression using data from the Million Veteran Program, 23andMe, UK Biobank and FinnGen, including individuals of European ancestry (n = 1,154,267; 340,591 cases) and African ancestry(n = 59,600; 25,843 cases).
Journal ArticleDOI
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.
Joel Gelernter,Ning Sun,Renato Polimanti,Robert H. Pietrzak,Daniel F. Levey,Julien Bryois,Qiongshi Lu,Yiming Hu,Boyang Li,Krishnan Radhakrishnan,Mihaela Aslan,Kei-Hoi Cheung,Yuli Li,Nallakkandi Rajeevan,Frederick G. Sayward,Kelly M. Harrington,Kelly M. Harrington,Quan Chen,Kelly Cho,Kelly Cho,Saiju Pyarajan,Saiju Pyarajan,Patrick F. Sullivan,Patrick F. Sullivan,Rachel Quaden,Yunling Shi,Haley Hunter-Zinck,J. Michael Gaziano,J. Michael Gaziano,John Concato,Hongyu Zhao,Murray B. Stein,Murray B. Stein,Million Veteran Program +33 more
TL;DR: This study identifies eight significant genetic associations with intrusive reexperiencing of trauma in post-traumatic stress disorder (PTSD) from the Million Veteran Program, a large biobank focused on US veterans.
Journal ArticleDOI
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.
Murray B. Stein,Murray B. Stein,Daniel F. Levey,Zhongshan Cheng,Frank R. Wendt,Kelly M. Harrington,Kelly M. Harrington,Gita A. Pathak,Kelly Cho,Kelly Cho,Rachel Quaden,Krishnan Radhakrishnan,Krishnan Radhakrishnan,Matthew J. Girgenti,Yuk-Lam Ho,Daniel C Posner,Mihaela Aslan,Ronald S. Duman,Hongyu Zhao,VA Million Veteran Program,VA Million Veteran Program,Renato Polimanti,John Concato,John Concato,Joel Gelernter +24 more
TL;DR: This paper conducted genome-wide association analyses of over 250,000 participants of European and African ancestry from the Million Veteran Program using electronic health record-validated post-traumatic stress disorder (PTSD) diagnosis and quantitative symptom phenotypes.
Journal ArticleDOI
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans
Tim B. Bigdeli,Ayman H. Fanous,Yuli Li,Nallakkandi Rajeevan,Frederick G. Sayward,Giulio Genovese,Giulio Genovese,Rishab Gupta,Krishnan Radhakrishnan,Anil K. Malhotra,Anil K. Malhotra,Ning Sun,Qiongshi Lu,Qiongshi Lu,Yiming Hu,Boyang Li,Quan Chen,Shrikant Mane,Perry L. Miller,Kei-Hoi Cheung,Raquel E. Gur,Tiffany A. Greenwood,David L. Braff,David L. Braff,Eric D. Achtyes,Peter F. Buckley,Michael Escamilla,Douglas S. Lehrer,Dolores Malaspina,Steven A. McCarroll,Steven A. McCarroll,Mark Hyman Rapaport,Marquis P. Vawter,Michele T. Pato,Carlos N. Pato,Genomic Psychiatry Cohort (Gpc) Investigators,Hongyu Zhao,Thomas R. Kosten,Mary Brophy,Saiju Pyarajan,Yunling Shi,Timothy J. O'Leary,Theresa Gleason,Ronald M. Przygodzki,Sumitra Muralidhar,J. Michael Gaziano,Million Veteran Program,Million Veteran Program,Grant D. Huang,John Concato,Larry J. Siever,Larry J. Siever,Mihaela Aslan,Philip D. Harvey,Philip D. Harvey +54 more
TL;DR: This work has demonstrated that published findings for SCZ and BIP are robustly generalizable to a diverse cohort of US veterans and reports 52 new susceptibility loci and improved fine-mapping resolution for dozens of previously reported associations.