M
Michel Bornens
Researcher at Curie Institute
Publications - 149
Citations - 17109
Michel Bornens is an academic researcher from Curie Institute. The author has contributed to research in topics: Centrosome & Microtubule. The author has an hindex of 69, co-authored 148 publications receiving 16178 citations. Previous affiliations of Michel Bornens include Centre national de la recherche scientifique.
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Journal ArticleDOI
The extracellular matrix guides the orientation of the cell division axis
Manuel Théry,Victor Racine,A. Pépin,Matthieu Piel,Yong Chen,Jean-Baptiste Sibarita,Michel Bornens +6 more
TL;DR: It is proposed that the ECM controls the location of actin dynamics at the membrane, and thus the segregation of cortical components in interphase and mitosis and is maintained on the cortex of mitotic cells and used for spindle orientation.
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Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity
Manuel Théry,Victor Racine,Matthieu Piel,A. Pépin,Ariane Dimitrov,Yong Chen,Jean-Baptiste Sibarita,Michel Bornens +7 more
TL;DR: It is demonstrated that ECM geometry determines the orientation of cell polarity axes and proposed a working model that accounts for that observation concludes that, in addition to molecular composition and mechanical properties,ECM geometry plays a key role in developmental processes.
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Centrosome composition and microtubule anchoring mechanisms.
TL;DR: The role of the centriole pair in controlling both the structural stability and the activity of theCentrosome in animal cells is now becoming clearer and the potential use of the generational asymmetry of centrosomes or spindle pole bodies for controlling cell polarity is growing theme.
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Protein interaction mapping: A Drosophila case study
Etienne Formstecher,Sandra Aresta,Vincent Collura,Alexandre Hamburger,Alain Meil,Alexandra Trehin,Céline Reverdy,Virginie Betin,Sophie Maire,Christine Brun,Bernard Jacq,Monique Arpin,Yohanns Bellaïche,Saverio Bellusci,Philippe Benaroch,Michel Bornens,Roland Chanet,Philippe Chavrier,Olivier Delattre,Valérie Doye,Richard G. Fehon,Richard G. Fehon,Gérard Faye,Thierry Galli,Jean-Antoine Girault,Bruno Goud,Jean de Gunzburg,Ludger Johannes,Marie-Pierre Junier,Vincent Mirouse,Ashim Mukherjee,Dora Papadopoulo,Franck Perez,Anne Plessis,Carine Rossé,Simon Saule,Dominique Stoppa-Lyonnet,Alain Vincent,Michael A. White,Pierre Legrain,Jérôme Wojcik,Jacques Camonis,Jacques Camonis,Laurent Daviet +43 more
TL;DR: This work used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries.
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The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells.
TL;DR: Time-lapse fluorescence microscopy reveals that the centriole pair inherited after mitosis splits during or just after telophase, and a model, based on differences in Mt anchoring and release by the mother and daughter centrioles is proposed to explain these results.