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Yasuko Ono
Researcher at Institute of Medical Science
Publications - 43
Citations - 2380
Yasuko Ono is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Calpain & Skeletal muscle. The author has an hindex of 25, co-authored 41 publications receiving 2148 citations. Previous affiliations of Yasuko Ono include University of Tokyo & University of Arizona.
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Journal ArticleDOI
Calpains: an elaborate proteolytic system.
Yasuko Ono,Hiroyuki Sorimachi +1 more
TL;DR: This article reviews the recent progress in calpain research, focusing on those studies that have helped to elucidate its mechanism of action and highlights the mechanistic characteristics shared by the numerous calpain homologs, despite the fact that they have divergent domain structures.
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Calpain research for drug discovery: challenges and potential
TL;DR: The calpain superfamily and calpain-related disorders are reviewed,Therapeutic strategies targeting malfunctions of calpains have been developed, driven primarily by improvements in the specificity and bioavailability of calpain inhibitors.
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Muscle RING-Finger Protein-1 (MuRF1) as a Connector of Muscle Energy Metabolism and Protein Synthesis
Suguru Koyama,Shoji Hata,Christian Witt,Yasuko Ono,Stefanie Lerche,Koichi Ojima,Tomoki Chiba,Naoko Doi,Fujiko Kitamura,Keiji Tanaka,Keiko Abe,Stephanie H. Witt,Vladimir Rybin,Alexander Gasch,Thomas Franz,Siegfried Labeit,Hiroyuki Sorimachi +16 more
TL;DR: Data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in theregulation of ATP synthesis under metabolic-stress conditions where Mu RF1 expression is induced.
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Specific interaction of the potassium channel β-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system
Tetsushi Furukawa,Yasuko Ono,Hiroyuki Tsuchiya,Yoshifumi Katayama,Marie Louise Bang,Dietmar Labeit,Siegfried Labeit,Nobuya Inagaki,Carol C. Gregorio +8 more
TL;DR: It is suggested that T-cap functions as an adapter protein to link together myofibrillar components with the membranous beta-subunit of the I(Ks) channel, providing a "mechano-electrical feedback" system in cardiac muscle.
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Calpain chronicle--an enzyme family under multidisciplinary characterization.
TL;DR: The study of calpains focuses especially on recent findings about their structure–function relationships, which have been greatly aided by the development of 3D structural studies and genetic models.