S
Suguru Koyama
Researcher at Institute of Medical Science
Publications - 4
Citations - 262
Suguru Koyama is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Calpain & Skeletal muscle. The author has an hindex of 4, co-authored 4 publications receiving 231 citations. Previous affiliations of Suguru Koyama include University of Tokyo.
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Journal ArticleDOI
Muscle RING-Finger Protein-1 (MuRF1) as a Connector of Muscle Energy Metabolism and Protein Synthesis
Suguru Koyama,Shoji Hata,Christian Witt,Yasuko Ono,Stefanie Lerche,Koichi Ojima,Tomoki Chiba,Naoko Doi,Fujiko Kitamura,Keiji Tanaka,Keiko Abe,Stephanie H. Witt,Vladimir Rybin,Alexander Gasch,Thomas Franz,Siegfried Labeit,Hiroyuki Sorimachi +16 more
TL;DR: Data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in theregulation of ATP synthesis under metabolic-stress conditions where Mu RF1 expression is induced.
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Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells.
TL;DR: It is hypothesized that the ‘signal complexes’ in the Z-, N2-, and M-lines modulate muscle cell homeostasis by transducing signals of external stimulations/stresses to trigger appropriate response at various different cellular events such as protein modification and gene expressions.
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Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array
Fumiko Shinkai-Ouchi,Suguru Koyama,Yasuko Ono,Shoji Hata,Koichi Ojima,Mayumi Shindo,David duVerle,Mika Ueno,Fujiko Kitamura,Naoko Doi,Ichigaku Takigawa,Hiroshi Mamitsuka,Hiroyuki Sorimachi +12 more
TL;DR: Calpains have a strict implicit rule for sequence specificity, and that the limited proteolysis of intact substrates is because of substrates' higher-order structures, which increases the understanding of calpain substrate specificities, and opens calpains to “next-generation,” i.e. activity-related quantitative and cooperativity-dependent analyses.
Journal ArticleDOI
Stomach-specific Calpain, nCL-2, Localizes in Mucus Cells and Proteolyzes the β-Subunit of Coatomer Complex, β-COP
Shoji Hata,Suguru Koyama,Suguru Koyama,Hiroyuki Kawahara,Naoko Doi,Tatsuya Maeda,Noriko Toyama-Sorimachi,Keiko Abe,Koichi Suzuki,Hiroyuki Sorimachi +9 more
TL;DR: Novel functions for nCL-2 that involve the membrane trafficking of mucus cells via interactions with coat protein are suggested.