S
Siegfried Labeit
Researcher at European Bioinformatics Institute
Publications - 9
Citations - 1092
Siegfried Labeit is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Titin & Myotilin. The author has an hindex of 7, co-authored 9 publications receiving 1028 citations. Previous affiliations of Siegfried Labeit include Laboratory of Molecular Biology.
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Journal ArticleDOI
Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.
Thomas Centner,Junko Yano,Eiichi Kimura,Abigail S. McElhinny,Katarina Pelin,Christian Witt,Marie Louise Bang,Karoly Trombitás,Henk Granzier,Carol C. Gregorio,Hiroyuki Sorimachi,Siegfried Labeit +11 more
TL;DR: A muscle specific RING finger protein, referred to as MURF-1, was identified in vitro to the titin repeats A168/A169 adjacent to the kinase domain this paper.
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Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.
TL;DR: The dual interactions of MURF-1 with titin and GMEB-1 may link myofibril signaling pathways (perhaps including titin's kinase domain) with muscle gene expression, suggesting the stability of the sarcomeric M-line region.
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Muscle RING-Finger Protein-1 (MuRF1) as a Connector of Muscle Energy Metabolism and Protein Synthesis
Suguru Koyama,Shoji Hata,Christian Witt,Yasuko Ono,Stefanie Lerche,Koichi Ojima,Tomoki Chiba,Naoko Doi,Fujiko Kitamura,Keiji Tanaka,Keiko Abe,Stephanie H. Witt,Vladimir Rybin,Alexander Gasch,Thomas Franz,Siegfried Labeit,Hiroyuki Sorimachi +16 more
TL;DR: Data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in theregulation of ATP synthesis under metabolic-stress conditions where Mu RF1 expression is induced.
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MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies.
Stephanie Hirner,Christian Krohne,Alexander Schuster,Sigrid Hoffmann,Stephanie H. Witt,Ralf Erber,Carsten Sticht,Alexander Gasch,Siegfried Labeit,Dittmar Labeit +9 more
TL;DR: The data demonstrate that MuRF1 expression in skeletal muscle re-directs glycogen synthesis to the liver and stimulates pancreatic insulin secretion, thereby providing a regulatory feedback loop that connects skeletal muscle metabolism with the Liver and the pancreas during metabolic stress.
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Immunoglobulin-type domains of titin : same fold, different stability ?
TL;DR: The stability of the modules over a range of conditions was investigated by measuring key thermodynamic parameters for both thermal and chemical denaturation and by monitoring amide proton exchange as a function of time.