K
Koichi Ojima
Researcher at National Agriculture and Food Research Organization
Publications - 61
Citations - 1775
Koichi Ojima is an academic researcher from National Agriculture and Food Research Organization. The author has contributed to research in topics: Skeletal muscle & Myosin. The author has an hindex of 21, co-authored 55 publications receiving 1524 citations. Previous affiliations of Koichi Ojima include Hokkaido University & University of Pennsylvania.
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Journal ArticleDOI
Muscle RING-Finger Protein-1 (MuRF1) as a Connector of Muscle Energy Metabolism and Protein Synthesis
Suguru Koyama,Shoji Hata,Christian Witt,Yasuko Ono,Stefanie Lerche,Koichi Ojima,Tomoki Chiba,Naoko Doi,Fujiko Kitamura,Keiji Tanaka,Keiko Abe,Stephanie H. Witt,Vladimir Rybin,Alexander Gasch,Thomas Franz,Siegfried Labeit,Hiroyuki Sorimachi +16 more
TL;DR: Data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in theregulation of ATP synthesis under metabolic-stress conditions where Mu RF1 expression is induced.
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Expression profiling of cytokines and related genes in regenerating skeletal muscle after cardiotoxin injection: a role for osteopontin.
Akira Hirata,Satoru Masuda,Tetsuo Tamura,Kazuko Kai,Koichi Ojima,Akiko Fukase,Kazuo Motoyoshi,Keiko Kamakura,Yuko Miyagoe-Suzuki,Shin'ichi Takeda +9 more
TL;DR: The expression of osteopontin (OPN), a versatile regulator of inflammation and tissue repair, was up-regulated more than 118-fold in regenerating muscle at 48 hours after injury and may be an important mediator in the early phase of muscle regeneration.
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Functional heterogeneity of side population cells in skeletal muscle.
Akiyoshi Uezumi,Koichi Ojima,So-ichiro Fukada,Madoka Ikemoto,Satoru Masuda,Yuko Miyagoe-Suzuki,Shin'ichi Takeda +6 more
TL;DR: The results revealed the heterogeneity of muscle SP cells and suggest that CD31(-)CD45(-) SP cells participate in muscle regeneration, showing the greatest myogenic potential among three SP sub-fractions, but indeed revealed mesenchymal potentials in vitro.
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Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy
Koichi Ojima,Yukiko Kawabata,Harumi Nakao,Kazuki Nakao,Naoko Doi,Fujiko Kitamura,Yasuko Ono,Shoji Hata,Hidenori Suzuki,Hiroyuki Kawahara,Julius Bogomolovas,Christian Witt,Coen A.C. Ottenheijm,Siegfried Labeit,Henk Granzier,Noriko Toyama-Sorimachi,Michiko Sorimachi,Koichi Suzuki,Koichi Suzuki,Tatsuya Maeda,Keiko Abe,Atsu Aiba,Hiroyuki Sorimachi +22 more
TL;DR: It is demonstrated that stretch-dependent p94 distribution in sarcomeres plays a crucial role in the pathogenesis of LGMD2A, and it is indicated that the stretch-induced dynamic redistribution of p94 is dependent on its protease activity and essential to protect muscle from degeneration, particularly under conditions of physical stress.
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Structural changes in the intramuscular connective tissue during development of bovine semitendinosus muscle
TL;DR: Structural changes in the intramuscular connective tissue during development of bovine semitendinosus muscle were investigated using the cell-maceration method for scanning electron microscopy, by which cellular elements were eliminated and collagen fibrils and fibres were exposed.