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Yaxiong Tang
Researcher at Chinese Academy of Sciences
Publications - 31
Citations - 774
Yaxiong Tang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 20 publications receiving 687 citations. Previous affiliations of Yaxiong Tang include University of California, Irvine.
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Journal ArticleDOI
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
David S. Yee,Yaxiong Tang,Yaxiong Tang,Xuesen Li,Zhongbo Liu,Yi Guo,Samia Ghaffar,Peter McQueen,Dash Atreya,Jun Xie,Anne R. Simoneau,Bang H. Hoang,Xiaolin Zi +12 more
TL;DR: Analysis of the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, WIF1, on the growth and cellular invasiveness of a bone metastatic PCa cell line, PC3, suggests that Wif1 regulates tumor invasion through EMT process and thus, may play an important role in controlling metastatic disease in PCa patients.
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WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
Yaxiong Tang,Anne R. Simoneau,Wu Xiang Liao,Guo Yi,Christopher Hope,Feng Liu,Shunqiang Li,Shunqiang Li,Jun Xie,Randall F. Holcombe,Frances Jurnak,Dan Mercola,Bang H. Hoang,Xiaolin Zi +13 more
TL;DR: Results suggest that mechanisms of WIF1-induced G1 arrest include SKP2 down-regulation leading to p27/Kip1 accumulation and c-myc down- regulation releasing p21/WAF1 transcription and shows that Wif1 inhibits in vivo bladder tumor growth in nude mice.
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Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
TL;DR: In this article, the effect of flavokawain B (FKB), a kava chalcone, is shown to be about 4- to 12-fold more effective in reducing the cell viabilities of androgen receptor (AR)-negative, HRPC cell lines DU145 and PC-3 than AR-positive, hormone-sensitive prostate cancer cell lines LAPC4 and LNCaP, with minimal effect on normal prostatic epithelial and stromal cells.
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Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53
TL;DR: In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G1 arrest, and induced a G2-M arrest in p53-defective cells.
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Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling
TL;DR: The data showed that Frzb expression was significantly inversely correlated with Met expression in both STS cell lines and tissues, suggesting the usefulness of Frzb in modulating Met signaling as a new treatment strategy for STS.