Yernaidu Reddi

TL;DR: In this article, the authors provide molecular insights into an NHC-catalyzed stereoselective annulation reaction between N-methylisatin and an enal leading to spirooxindole lactone in the presence of LiCl as the Lewis acid.

TL;DR: Improved enantioselectivity is predicted from 37% to 89% by changes in the N-aryl substituents of the catalyst, helped by molecular insights on the enantiocontrolling transition states.

TL;DR: The Breslow intermediate as discussed by the authors is formed by the nucleophilic addition of an NHC to a carbonyl group of a suitable electrophile, and it has been shown that a direct 1,2-proton transfer within the initial zwitterionic intermediate is energetically prohibitive and hence the participation of other species capable of promoting an assisted proton transfer is more likely.

TL;DR: In this paper , a comprehensive, integrated approach to summarize important and impactful contributions to this broad research arena is presented, highlighting signature accomplishments across a broad research portfolio and is organized into four wide-ranging research themes that address the topic in a comprehensive manner: Feedstocks, Polymerization Processes and Techniques, Intended Use, and End of Use.

TL;DR: BINAM-derived phosphoric acid catalysts were shown to prevent alkene isomerization in cyclopentene and cycloheptene starting materials and DFT(B3LYP-D3) computations revealed that increased product selectivity resulted from a chiral anion dependent lowering of the activation barrier for the desired pathway.