Yesi Shi

TL;DR: This sonotheranostics significantly enhances the SDT effect of porphyrin through the cancer‐targeted delivery capability and enhanced reactive oxygen species production via triple‐regulated approaches, including down‐regulation of SOD2, depletion of glutathione, and generation of Fenton reaction.

TL;DR: The inherent excellent magnetic-heat capability, coupled with catalysis-triggered tumor suppression, allows eMIONs to provide an MRI-guided magneto-catalytic combination therapy, which may open up a new avenue for bench-to-bed translational research of MHT.

TL;DR: A simple and efficient strategy for fabricating the α-syn nanoscavenger for PD via a reprecipitation self-assembly procedure is developed, which provides a clinically translatable therapeutic strategy aimed at neuroprotection and disease modification in PD.

TL;DR: This work proposed and validated a nanoparticle-based broad-spectrum anti-inflammatory strategy for RA management by fusing TRAIL-anchored cell membranes onto drug-loaded polymeric cores (TU-NPs), which makes them ideal decoys of inflamed macrophage-targeted biological molecules.

TL;DR: The TME-responsive “Fenton Nanoreactor” provides a promising strategy with enhanced translational potency for tumor therapy and an imaging-guided chemodynamic treatment, featuring excellent antitumor efficiency and biosafety.