Y
Yi Zheng
Researcher at University of Tennessee Health Science Center
Publications - 41
Citations - 5334
Yi Zheng is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: GTPase & Guanine nucleotide exchange factor. The author has an hindex of 36, co-authored 41 publications receiving 5184 citations. Previous affiliations of Yi Zheng include Cornell University.
Papers
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Journal ArticleDOI
The Dbl family of oncogenes.
Richard A. Cerione,Yi Zheng +1 more
TL;DR: There is still a good deal to learn regarding the biochemical mechanisms that underlie the Dbl family of proteins, and these positive regulators of G proteins to specific cellular locations to carry out the signaling task.
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Dbl family guanine nucleotide exchange factors
TL;DR: The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases.
Journal ArticleDOI
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
TL;DR: It is suggested that PI 3-kinase, through the Rho-GAP homology domain of p85, can couple to the effector domain of Cdc42Hs and that p85 may be a target for the GTP-bound forms of CDC42HS and Rac1.
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Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
Matthew J. Hart,Alessandra Eva,Daniela Zangrilli,Stuart A. Aaronson,Tony Evans,Richard A. Cerione,Yi Zheng +6 more
TL;DR: It is established that a minimal unit on Dbl that is critical to its transforming function directly regulates GDP-GTP exchange activity, and which inactivate transformation eliminated the ability of Dbl to stimulate GDP dissociation.
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Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
TL;DR: Results suggest that GEF-H1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.