Yibang Chen

TL;DR: It is reported herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF, and it is identified as a natural ligand forCD74, which has been implicated previously in signaling and accessory functions for immune cell activation.

TL;DR: It is shown that Toll-like receptors, including TLR4, are expressed on tumor cells from a wide variety of tissues, suggesting that TLR activation may be an important event in tumor cell immune evasion.

TL;DR: It is shown that recombinant D-DT protein binds CD74 with high affinity, leading to activation of ERK1/2 MAP kinase and downstream proinflammatory pathways, and the specific immunoneutralization of D- DT protects mice from lethal endotoxemia by reducing the expression of downstream effector cytokines.

TL;DR: PKA treatment of recombinant AC6 in insect cell membranes results in a selective loss of stimulation by high (>10 nM) concentrations of Galphas, suggesting a mechanism of how isoform selective regulatory diversity can be obtained within conserved regions involved in signal communication.

TL;DR: Genetic evidence is provided that MIF's intrinsic tautomerase activity is dispensable for this cytokine's growth-regulatory properties and support a role for the N-terminal region in protein-protein interactions.