Yicheng Wang

TL;DR: This work demonstrates the feasibility of reconstructing genetic lineages and tracing their epigenomic and transcriptomic dynamics with single-cell multiomics sequencing and showed that DNA methylation levels are consistent within lineages but can differ substantially among clones.

TL;DR: Zhang et al. as mentioned in this paper found that EGFR+ cells are mainly distributed in the germinal zone and frequently colocalize with the stemness marker SOX2 during this period, which corresponds to the beginning stages of human gliogenesis.

TL;DR: This study characterizes the critical genetic, epigenetic, and transcriptomic features and their mutual regulatory relationships in ovarian cancer, providing valuable resources for identifying new molecular mechanisms and potential therapeutic targets for HGSC.

TL;DR: It is demonstrated that CATSPer1 might maintain CRC malignant process partly through the activation of the PI3K/AKT signaling pathway, suggesting that targeting CATSPER1 might represent a promising strategy for colon cancer treatment.

TL;DR: In this paper , the authors performed multi-regional sampling, parallel single-cell multi-omics sequencing and integrated analyses of human gastric cancer, and revealed the singlecell DNA methylome landscape of Gastric cancer and identified candidate DNA methylation biomarkers, such as hypermethylated promoters of TMEM240 and HAGLROS.