Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex.
Yuanyuan Fu,Ming Yang,Hongmin Yu,Yicheng Wang,Xinglong Wu,Jun Yong,Y. J. Mao,Y. J. Mao,Yueli Cui,Yueli Cui,Xiaoying Fan,Lu Wen,Lu Wen,Jie Qiao,Fuchou Tang +14 more
TLDR
Zhang et al. as mentioned in this paper found that EGFR+ cells are mainly distributed in the germinal zone and frequently colocalize with the stemness marker SOX2 during this period, which corresponds to the beginning stages of human gliogenesis.About:
This article is published in Cell Reports.The article was published on 2021-03-02 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Neurogenesis & Subventricular zone.read more
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The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Ilon Liu,Li Jiang,Erik R Samuelsson,Sergio Marco Salas,Alexander M. Beck,Olivia A Hack,Dae Hune Jeong,McKenzie Shaw,Bernhard Englinger,Jenna LaBelle,Hafsa M Mire,Sibylle Madlener,Lisa Mayr,Michael Quezada,Maria Trissal,Eshini Panditharatna,Kati Ernst,Jayne Vogelzang,Taylor A. Gatesman,Matthew E Halbert,Hana Pálová,Petra Pokorná,Jaroslav Sterba,Ondrej Slaby,René Geyeregger,Aaron Diaz,Izac J. Findlay,Matthew D. Dun,Adam C. Resnick,Mario L. Suvà,David T. Jones,Sameer Agnihotri,Jessica Svedlund,Carl Koschmann,Christine Haberler,Thomas Czech,Irene Slavc,Jennifer A. Cotter,Keith L. Ligon,Sanda Alexandrescu,W. K. Alfred Yung,Isabel Arrillaga-Romany,Johannes Gojo,Michelle Monje,Mats Nilsson,Mariella G. Filbin +45 more
TL;DR: In this paper , the authors dissected the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, delineating how age and anatomical location shape glioma cell-intrinsic and -extrinsics features in light of the shared driver mutation.
Journal ArticleDOI
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis.
David van Bruggen,Fabio Pohl,Christoffer Mattsson Langseth,Petra Kukanja,Hower Lee,Alejandro Mossi Albiach,Mukund Kabbe,Mandy Meijer,Sten Linnarsson,Markus M. Hilscher,Mats Nilsson,Erik Sundström,Gonçalo Castelo-Branco +12 more
TL;DR: Using single-cell RNA sequencing, the authors found evidence of the emergence of a first wave of oligodendrocyte lineage cells as early as post-conception weeks (PCW) 8-10.
Journal ArticleDOI
Human neural organoids: Models for developmental neurobiology and disease.
TL;DR: A review of human neural organoid systems, how they are generated, advances in 3D imaging and bioengineering, and the impact of organoid studies on our understanding of the human nervous system can be found in this paper.
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Insights into Alzheimer’s disease from single-cell genomic approaches
Mitchell H. Murdock,Li-Huei Tsai +1 more
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Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain
Elizabeth E. Crouch,Aparna Bhaduri,Madeline G. Andrews,Arantxa Cebrián-Silla,Loukas N. Diafos,Janeth Ochoa Birrueta,Kaylee Wedderburn-Pugh,Edward J. Valenzuela,Neal K. Bennett,Ugomma C. Eze,Carmen Sandoval-Espinosa,Jiapei Chen,Cristina Mora,Jayden M. Ross,Clare Elisabeth Howard,Susana González-Granero,Jaime Ferrer Lozano,Máximo Vento,Maximilian Haeussler,Mercedes F. Paredes,K. Nakamura,José Manuel García-Verdugo,Arturo Alvarez-Buylla,Arnold R. Kriegstein,Eric J. Huang +24 more
TL;DR: Using fluorescence-activated cell sorting, single-cell transcriptomics, and histological and ultrastructural analyses, the authors showed that an ensemble of endothelial and mural cell subtypes tile the brain vasculature during the second trimester.
References
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STAR: ultrafast universal RNA-seq aligner
Alexander Dobin,Carrie A. Davis,Felix Schlesinger,Jorg Drenkow,Chris Zaleski,Sonali Jha,Philippe Batut,Mark Chaisson,Thomas R. Gingeras +8 more
TL;DR: The Spliced Transcripts Alignment to a Reference (STAR) software based on a previously undescribed RNA-seq alignment algorithm that uses sequential maximum mappable seed search in uncompressed suffix arrays followed by seed clustering and stitching procedure outperforms other aligners by a factor of >50 in mapping speed.
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featureCounts: an efficient general-purpose program for assigning sequence reads to genomic features
TL;DR: FeatureCounts as discussed by the authors is a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments, which implements highly efficient chromosome hashing and feature blocking techniques.
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Comprehensive Integration of Single-Cell Data.
Tim Stuart,Andrew Butler,Paul J. Hoffman,Christoph Hafemeister,Efthymia Papalexi,William M. Mauck,Yuhan Hao,Marlon Stoeckius,Peter Smibert,Rahul Satija +9 more
TL;DR: A strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities.
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Integrating single-cell transcriptomic data across different conditions, technologies, and species.
TL;DR: An analytical strategy for integrating scRNA-seq data sets based on common sources of variation is introduced, enabling the identification of shared populations across data sets and downstream comparative analysis.
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Robust enumeration of cell subsets from tissue expression profiles
Aaron M. Newman,Chih Long Liu,Michael R. Green,Andrew J. Gentles,Weiguo Feng,Yue Xu,Chuong D. Hoang,Maximilian Diehn,Arash Ash Alizadeh +8 more
TL;DR: CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types when applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors.
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