H
Huiping Liu
Researcher at Northwestern University
Publications - 83
Citations - 5639
Huiping Liu is an academic researcher from Northwestern University. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 33, co-authored 67 publications receiving 4529 citations. Previous affiliations of Huiping Liu include Stanford University & Case Western Reserve University.
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Journal ArticleDOI
Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
Yohei Shimono,Maider Zabala,Robert W. Cho,Neethan A. Lobo,Piero Dalerba,Dalong Qian,Maximilian Diehn,Huiping Liu,Sarita Panula,Eric Chiao,Frederick M. Dirbas,George Somlo,Renee A. Reijo Pera,Kaiqin Lao,Michael F. Clarke +14 more
TL;DR: The coordinated downregulation of three microRNA clusters and the similar functional regulation of clonal expansion by miR-200c provide a molecular link that connects BCSCs with normal stem cells.
Journal ArticleDOI
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
Huiping Liu,Manishkumar Patel,Jennifer A. Prescher,Antonia Patsialou,Dalong Qian,Jiahui Lin,Susanna Wen,Ya Fang Chang,Ya Fang Chang,Michael Bachmann,Yohei Shimono,Piero Dalerba,Maddalena Adorno,Neethan A. Lobo,Janet Bueno,Frederick M. Dirbas,Sumanta Goswami,George Somlo,John S. Condeelis,Christopher H. Contag,Sanjiv S. Gambhir,Michael F. Clarke +21 more
TL;DR: These metastatic cancer models, combined with noninvasive imaging techniques, constitute an integrated approach that could be applied to dissect the molecular mechanisms underlying the dissemination of metastatic CSCs (MCSCs) and to explore therapeutic strategies targeting MCSCs in general or to evaluate individual patient tumor cells and predict response to therapy.
Journal ArticleDOI
Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models
Xia Liu,Rokana Taftaf,Madoka Kawaguchi,Ya Fang Chang,Wenjing Chen,David Entenberg,Youbin Zhang,Lorenzo Gerratana,Lorenzo Gerratana,Simo Huang,Dhwani Patel,Elizabeth Tsui,Valery Adorno-Cruz,Valery Adorno-Cruz,Steven M. Chirieleison,Yue Cao,Allison S. Harney,Shivani A. Patel,Antonia Patsialou,Yang Shen,Stefanie Avril,Hannah Gilmore,Justin D. Lathia,Justin D. Lathia,Derek W. Abbott,Massimo Cristofanilli,John S. Condeelis,Huiping Liu +27 more
TL;DR: It is found that clustered tumor cells in migration and circulation resulted from aggregation of individual tumor cells rather than collective migration and cohesive shedding, which will lead to innovative biomarker applications to predict prognosis, facilitate development of new targeting strategies to block polyclonal metastasis, and improve clinical outcomes.
Journal ArticleDOI
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
Jessica Bockhorn,Rachel Dalton,Chika Nwachukwu,Simo Huang,Aleix Prat,Kathy Yee,Ya Fang Chang,Dezheng Huo,Yujia Wen,Kaitlin E. Swanson,Tyler Qiu,Jun Lu,Seo Young Park,M. Eileen Dolan,Charles M. Perou,Olufunmilayo I. Olopade,Michael F. Clarke,Geoffrey L. Greene,Huiping Liu,Huiping Liu +19 more
TL;DR: It is demonstrated that microRNA-30c is transcriptionally regulated by GATA3 in breast tumours and inversely correlates with interleukin-11 expression in primary breast tumour patients, and low interleuko-11 correlates with relapse-free survival in breast cancer patients.
Journal ArticleDOI
Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance
Valery Adorno-Cruz,Golam Kibria,Xia Liu,Mary R. Doherty,Damian J. Junk,Dongyin Guan,Christopher G. Hubert,Monica Venere,Erin E. Mulkearns-Hubert,Maksim Sinyuk,Alvaro G. Alvarado,Arnold I. Caplan,Jeremy N. Rich,Jeremy N. Rich,Stanton L. Gerson,Justin D. Lathia,Justin D. Lathia,Huiping Liu +17 more
TL;DR: The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts.