Y
Yoko Tomobe
Researcher at University of Tsukuba
Publications - 14
Citations - 11360
Yoko Tomobe is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin 1 & Mesenteric arteries. The author has an hindex of 10, co-authored 14 publications receiving 11184 citations.
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Journal ArticleDOI
A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
Masashi Yanagisawa,Hiroki Kurihara,Hiroki Kurihara,Sadao Kimura,Yoko Tomobe,Mieko Kobayashi,Youji Mitsui,Yoshio Yazaki,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
Journal ArticleDOI
Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats.
Yoko Tomobe,Takashi Miyauchi,Akira Saito,Masashi Yanagisawa,Sadao Kimura,Katsutoshi Goto,Tomoh Masaki +6 more
Journal ArticleDOI
Involvement of endothelin in the regulation of human vascular tonus. Potent vasoconstrictor effect and existence in endothelial cells.
Takashi Miyauchi,Yoko Tomobe,Reiko Shiba,Tomohisa Ishikawa,Masashi Yanagisawa,Sadao Kimura,Yasuro Sugishita,Iwao Ito,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: The results of the present study indicate that endothelin-1 is one of the most potent vasoconstrictors in the human mesenteric artery and that it induces vasoconStrictor action via an ultimately accelerating Ca2+ influx through voltage-dependent Ca2- channels.
Journal ArticleDOI
Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats
Nobuhiro Suzuki,Takashi Miyauchi,Yoko Tomobe,Hirokazu Matsumoto,Katsutoshi Goto,Tomoh Masaki,Masahiko Fujino +6 more
TL;DR: Findings of the plasma ET-1 levels suggest that the role ofET-1 in the vascular control system may be different in DOCA-salt hypertensive rats and genetically hypertensive Rats.
Journal ArticleDOI
Characteristics of pressor response to endothelin in spontaneously hypertensive and Wistar-Kyoto rats.
Takashi Miyauchi,Tomohisa Ishikawa,Yoko Tomobe,Masashi Yanagisawa,Sadao Kimura,Yasuro Sugishita,Iwao Ito,Katsutoshi Goto,Tomoh Masaki +8 more
TL;DR: Evidence is provided that endothelin produces a unique, potent, and long-lasting pressor response, which appears to be in part related to the activation of Ca2+ channels.