Y
Youji Mitsui
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 212
Citations - 19650
Youji Mitsui is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Cell culture & Cell. The author has an hindex of 52, co-authored 212 publications receiving 19281 citations. Previous affiliations of Youji Mitsui include Japanese Ministry of International Trade and Industry & Institute of Molecular and Cell Biology.
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Journal ArticleDOI
A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
Masashi Yanagisawa,Hiroki Kurihara,Hiroki Kurihara,Sadao Kimura,Yoko Tomobe,Mieko Kobayashi,Youji Mitsui,Yoshio Yazaki,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
Journal ArticleDOI
The relationship between in vitro cellular aging and in vivo human age.
Edward L. Schneider,Youji Mitsui +1 more
TL;DR: Although early and late passage cultures of human diploid cells may provide an important cell system for examining loss of replicative potential, fibroblast cultures derived from old and young human donors may be a more appropriate model system for studying human cellular aging.
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The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.
TL;DR: The whole length of the human preproendothelin-1 gene and the corresponding cDNA and the complete nucleotide sequences are cloned and suggest that the regulation of expression of PPET-1 mRNA may be mediated in part by these sequence elements.
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Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin
Yasuaki Itoh,Masashi Yanagisawa,Shoichi Ohkubo,Chiharu Kimura,Takuo Kosaka,Akihiro Inoue,Norio Ishida,Youji Mitsui,Haruo Onda,Masahiko Fujino,Tomoh Masaki +10 more
TL;DR: A cDNA encoding a human endothelium‐derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library and showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine prepro Endothelin.
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A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity.
TL;DR: A new peptide family (endothelin (ET) consisting of three members in mammals appears to be present in mice according to genomic Southern blot analysis, and a novel peptide was synthesized and confirmed to have in vivo pressor activity similar to that of ET.