Yoshihiko Ikeguchi

TL;DR: The clinical features observed in SRS are consistent with cerebellar dysfunction and a defective functioning of red nucleus neurons, which, at least in rats, contain high levels of spermine, and the presence of MR reflects a role for s permine in cognitive function, possibly by sper mine's ability to function as an ‘intrinsic gateway’ molecule for inward rectifier K+ channels.

TL;DR: The crystal structure of the PAPT from Thermotoga maritima has been solved to 1.5 Å resolution and reveals deep cavities for binding substrate and cofactor, and a loop that envelops the active site, suggesting a universal catalytic mechanism.

TL;DR: The spermine synthase·5′-methylthioadenosine structure provides a plausible explanation for the potent inhibition of the reaction by this product and the stronger inhibition of spermining synthase compared with spermidine synthase.

TL;DR: Comparison of the structures of the human spermidine synthase with both substrates and products and analysis of the properties of site-directed mutants provide a general mechanistic hypothesis for the aminopropyl transfer reaction.

TL;DR: It is shown that spermine synthesis is needed for normal growth, viability, and fertility in male mice and that regulation of sPermine synthase content is not required.