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Yosuke Omae
Researcher at University of Tokyo
Publications - 53
Citations - 719
Yosuke Omae is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 30 publications receiving 497 citations.
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Journal ArticleDOI
Transcription and Translation Products of the Cytolysin Gene psm-mec on the Mobile Genetic Element SCCmec Regulate Staphylococcus aureus Virulence
Chikara Kaito,Yuki Saito,Gentaro Nagano,Mariko Ikuo,Yosuke Omae,Yuichi Hanada,Xiao-Yan Han,Kyoko Kuwahara-Arai,Tomomi Hishinuma,Tadashi Baba,Teruyo Ito,Keiichi Hiramatsu,Kazuhisa Sekimizu +12 more
TL;DR: Findings suggest that both the psm-mec transcript, acting as a regulatory RNA, and the PSM- mec protein encoded by the gene on the mobile genetic element SCCmec regulate the virulence of Staphylococcus aureus.
Journal ArticleDOI
Mobile Genetic Element SCCmec-encoded psm-mec RNA Suppresses Translation of agrA and Attenuates MRSA Virulence
Chikara Kaito,Yuki Saito,Mariko Ikuo,Yosuke Omae,Han Mao,Gentaro Nagano,Tomoko Fujiyuki,Shunsuke Numata,Xiao-Na Han,Kazuaki Obata,Setsuo Hasegawa,Hiroki Yamaguchi,Koiti Inokuchi,Teruyo Ito,Keiichi Hiramatsu,Kazuhisa Sekimizu +15 more
TL;DR: It is reported that psm-mec RNA inhibits translation of the agrA gene encoding a positive transcription factor for the PSMα gene via specific binding to agRA mRNA, which suppresses MRSA virulence via inhibition of agr a translation and the absence of psm -mec function in CA-MRSA causes its high virulence property.
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Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population
Xiaoyuan Jia,Tomoko Horinouchi,Yuki Hitomi,Akemi Shono,Seik-Soon Khor,Yosuke Omae,Kaname Kojima,Yosuke Kawai,Masao Nagasaki,Yoshitsugu Kaku,Takayuki Okamoto,Yoko Ohwada,Kazuhide Ohta,Yusuke Okuda,Rika Fujimaru,Ken Hatae,Naonori Kumagai,Emi Sawanobori,Hitoshi Nakazato,Yasufumi Ohtsuka,Koichi Nakanishi,Yuko Shima,Ryojiro Tanaka,Akira Ashida,Koichi Kamei,Kenji Ishikura,Kandai Nozu,Katsushi Tokunaga,Kazumoto Iijima +28 more
TL;DR: The most significant association with childhood SSNS was detected in the HLA-DR/DQ region and replicated and was identified as the most significant genetic susceptibility factor.
Journal ArticleDOI
A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus.
Chikara Kaito,Yosuke Omae,Yasuhiko Matsumoto,Makiko Nagata,Hiroki Yamaguchi,Taiji Aoto,Teruyo Ito,Keiichi Hiramatsu,Kazuhisa Sekimizu +8 more
TL;DR: It is suggested that fudoh in the SCCmec type-II region suppresses colony spreading and exotoxin production, and is involved in S. aureus pathogenesis.
Journal ArticleDOI
Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis.
Yosuke Omae,Licht Toyo-oka,Hideki Yanai,Supalert Nedsuwan,Sukanya Wattanapokayakit,Nusara Satproedprai,Nat Smittipat,Prasit Palittapongarnpim,Pathom Sawanpanyalert,Wimala Inunchot,Ekawat Pasomsub,Nuanjun Wichukchinda,Taisei Mushiroda,Michiaki Kubo,Katsushi Tokunaga,Surakameth Mahasirimongkol +15 more
TL;DR: The results suggested that host genetic risk in TB is depended upon the pathogen genetic background and demonstrate the importance of analyzing the interaction between host and pathogen genomes in TB.