Douglas M. Molina

TL;DR: A protein microarray was developed and used to probe plasma from 220 individuals in Mali and provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features, which could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf.

TL;DR: Using malaria as a model, a method is reported which elucidates the profile of antibodies that develop after natural or experimental infection or after vaccination with attenuated organisms, and which identifies immunoreactive antigens of interest for vaccine development or other applications.

TL;DR: A systems immunology approach integrating clinical data and bacterial metabolic and regulatory information with high-throughput detection in human serum of antibodies to the entire Mycobacterium tuberculosis proteome defines the M. tuberculosis immunoproteome, which is rich in membrane-associated and extracellular proteins.

TL;DR: Results show that microarrays allow a more comprehensive analysis of the immune response on an antigen- specific, patient-specific, and population-specific basis, can identify serodiagnostic antigens, and contribute to a more detailed understanding of immunogenicity to this pathogen.

TL;DR: The data provide the first evidence that sterile protective immunity against malaria is directed against a panel of novel P. falciparum antigens rather than one antigen in isolation, suggesting that an efficacious malaria vaccine should be multivalent and targeted at a select panel of key antIGens, many of which have not been previously characterized.