Yu Huan Tsai

TL;DR: This study integrated human epidemiological and clinical data with bacterial population genomics to harness the biodiversity of the model foodborne pathogen Listeria monocytogenes and decipher the basis of its neural and placental tropisms.

TL;DR: In vitro and in vivo approaches using intestinal and placental mouse and human tissues find a differential requirement for InlA and InlB in tissue invasiveness, with a critical role for PI3K activation.

TL;DR: It is demonstrated that, unexpectedly, murinized InlA (InlAm) mediates not only Ecad-dependent internalization, but also N-cadherin-dependentinternalization, which results in enhanced innate immune responses and intestinal barrier damage, which are not observed in wild-type Lm-infected humanized mice.

TL;DR: In this article , the authors developed a clinically relevant experimental model of neuro-listeriosis, using hypervirulent neuroinvasive strains inoculated in a humanized mouse model of infection, and showed that the bacterial surface protein InlB protects infected monocytes from Fas-mediated cell death by CD8+ T cells in a manner that depends on c-Met, PI3 kinase and FLIP.

TL;DR: The genomic characterization of a nationwide dataset of 411 clinical and 82 food isolates collected in Taiwan between 2014 and 2019 shows a 9-fold increase in listeriosis reporting upon implementation of mandatory notification, highlighting the importance of genome sequencing for a detailed characterization of the pathogenic L. monocytogenes genotypes circulating in Asia.