Yu Toyoda

TL;DR: The historical background and discovery of the ATP-driven xenobiotic export pumps encoded by MRP genes, biological functions of ABC transporters belonging to the MRP class, and regulation of gene expression of MRPs by oxidative stress are addressed.

TL;DR: A genome-wide association study of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific, and this work leads to a novel concept for the therapeutic target of g out/hyperuricaemia.

TL;DR: This mini-review provides integrated information covering the technical backgrounds necessary to evaluate the ABCG2 inhibitory effects on the target compounds and a current update on theABCG2 inhibitors, as febuxostat is serendipitously identified as a well-used agent for hyperuricemia as a strong ABCG1 inhibitor that possesses some promising potentials.

TL;DR: It is proposed that the N‐linked glycan at Asn596 is important for stabilizing de’novo‐synthesized ABCG2 and that disruption of this linkage results in protein destabilization and enhanced ubiquitin‐mediated proteasomal degradation.

TL;DR: The evidence is provided that this genetic polymorphism has an effect on the Alinked glycosylation of ABCC11, intracellular sorting, and proteasomal degradation of the variant protein.