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Ituro Inoue
Researcher at National Institute of Genetics
Publications - 185
Citations - 7265
Ituro Inoue is an academic researcher from National Institute of Genetics. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 44, co-authored 172 publications receiving 6220 citations. Previous affiliations of Ituro Inoue include Tokai University & University of Tokyo.
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Journal ArticleDOI
Genome-wide association study of intracranial aneurysm identifies three new risk loci
Katsuhito Yasuno,Kaya Bilguvar,Philippe Bijlenga,Siew-Kee Low,Boris Krischek,Georg Auburger,Matthias Simon,Dietmar Krex,Zulfikar Arlier,Nikhil R. Nayak,Ynte M. Ruigrok,Mika Niemelä,Atsushi Tajima,Mikael von und zu Fraunberg,Tamás Dóczi,Florentina Wirjatijasa,Akira Hata,Jordi Blasco,Ági Oszvald,Hidetoshi Kasuya,Gulam Zilani,Beate Schoch,Pankaj Singh,Pankaj Singh,Carsten Stüer,Roelof Risselada,Jürgen Beck,Teresa Sola,Filomena Ricciardi,Arpo Aromaa,Thomas Illig,Stefan Schreiber,Cornelia M. van Duijn,Leonard H. van den Berg,Claire Perret,Carole Proust,Constantin Roder,Ali K. Ozturk,Emilia I. Gaal,Daniela Berg,Christof Geisen,Christoph M. Friedrich,Paul Summers,Alejandro F. Frangi,Alejandro F. Frangi,Matthew W. State,H.-Erich Wichmann,Monique M.B. Breteler,Cisca Wijmenga,Shrikant Mane,Leena Peltonen,Leena Peltonen,Vivas Elio,Miriam C. J. M. Sturkenboom,Patricia V. Lawford,James V. Byrne,Juan Macho,Erol I. Sandalcioglu,Bernhard Meyer,Andreas Raabe,Helmuth Steinmetz,Daniel A. Rüfenacht,Juha E. Jääskeläinen,Juha Hernesniemi,Gabriel J.E. Rinkel,Hitoshi Zembutsu,Ituro Inoue,Aarno Palotie,Aarno Palotie,François Cambien,Yusuke Nakamura,Richard P. Lifton,Murat Gunel +72 more
TL;DR: Two new loci showing strong evidence for association with intracranial aneurysms are identified and several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair.
Journal ArticleDOI
Susceptibility loci for intracranial aneurysm in European and Japanese populations.
Kaya Bilguvar,Katsuhito Yasuno,Mika Niemelä,Ynte M. Ruigrok,Mikael von und zu Fraunberg,Cornelia M. van Duijn,Leonard H. van den Berg,Shrikant Mane,Christopher E. Mason,Murim Choi,Emilia Gaál,Emilia Gaál,Yasar Bayri,Luis Kolb,Zulfikar Arlier,Sudhakar Ravuri,Antti Ronkainen,Atsushi Tajima,Aki Laakso,Akira Hata,Hidetoshi Kasuya,Timo Koivisto,Jaakko Rinne,Juha Öhman,Monique M.B. Breteler,Cisca Wijmenga,Cisca Wijmenga,Matthew W. State,Gabriel J.E. Rinkel,Juha Hernesniemi,Juha E. Jääskeläinen,Aarno Palotie,Aarno Palotie,Ituro Inoue,Richard P. Lifton,Murat Gunel +35 more
TL;DR: Genome-wide genotyping of Finnish, Dutch and Japanese cohorts and replication studies in the Japanese cohort identified common SNPs on chromosomes 2q, 8q and 9p that show significant association with intracranial aneurysm with odds ratios 1.24–1.36.
Journal ArticleDOI
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
Kazuaki Suda,Hirofumi Nakaoka,Kosuke Yoshihara,Tatsuya Ishiguro,Ryo Tamura,Yutaro Mori,Kaoru Yamawaki,Sosuke Adachi,Tomoko Takahashi,Hiroaki Kase,Kenichi Tanaka,Tadashi Yamamoto,Teiichi Motoyama,Ituro Inoue,Takayuki Enomoto +14 more
TL;DR: Remarkable increases in MAF of mutations in cancer-associated genes in endometriotic epithelium suggest retrograde flow of endometrial cells already harboring cancer- associated mutations, with selective advantages at ectopic sites, leading to the development ofendometriosis.
Journal ArticleDOI
Next-generation sequencing: impact of exome sequencing in characterizing Mendelian disorders.
TL;DR: Combination of WES with traditional approaches, consistent with linkage analysis, has had the greatest impact on those disorders following autosomal mode of inheritance; in more than 60 identified genes, the causal variants have been transmitted at homozygous or compound heterozygous state.
Journal ArticleDOI
Regulation of the hepatitis C virus genome replication by miR-199a
TL;DR: The results of this study suggest that miR-199a directly regulates HCV replication and may serve as a novel antiviral therapy.