Y
Yu Zhan
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 15
Citations - 612
Yu Zhan is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: MAP kinase kinase kinase & ASK1. The author has an hindex of 10, co-authored 14 publications receiving 499 citations. Previous affiliations of Yu Zhan include University of Toledo & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Application of Box-Behnken design in optimisation for polysaccharides extraction from cultured mycelium of Cordyceps sinensis
TL;DR: In this paper, a three-level Box-Behnken design combined with the canonical and ridge analyses was employed to optimise the process parameters for polysaccharide extraction from cultured mycelium of Cordyceps sinensis, one of the most valued traditional Chinese medicines and health foods.
Journal ArticleDOI
Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury
Yu Zhan,Po Ju Chen,William D. Sadler,Fuyuan Wang,Sara A. Poe,Gabriel Núñez,Kathryn A. Eaton,Grace Y. Chen +7 more
TL;DR: Although commensal bacteria are capable of driving chronic inflammation and tumorigenesis, the gut microbiota also have important roles in limiting chemically induced injury and proliferative responses that lead to tumor development.
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A survey of the geographic distribution of Ophiocordyceps sinensis.
Yi Li,Xiao-Liang Wang,Lei Jiao,Yi Jiang,Hui Li,Si-Ping Jiang,Ngarong Lhosumtseiring,Shen-Zhan Fu,Caihong Dong,Yu Zhan,Yi-Jian Yao +10 more
TL;DR: Distribution of O. sinensis at the county level is clarified in this work based on both a literature search and fieldwork, which shows that the fungus is confined to the Tibetan Plateau and its surrounding regions.
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Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
Shipra Shukla,Joanna Cyrta,Devan Murphy,Edward Walczak,Leili Ran,Praveen Agrawal,Yuanyuan Xie,Yuedan Chen,Shangqian Wang,Yu Zhan,Dan Li,Elissa W.P. Wong,Andrea Sboner,Himisha Beltran,Juan Miguel Mosquera,Jessica Sher,Zhen Cao,John Wongvipat,Richard Koche,Anuradha Gopalan,Deyou Zheng,Mark A. Rubin,Howard I. Scher,Howard I. Scher,Ping Chi,Ping Chi,Yu Chen,Yu Chen +27 more
TL;DR: An aberrant gastrointestinal-lineage transcriptome expressed in ∼5% of primary prostate cancer that is characterized by abbreviated response to androgen-deprivation therapy and in ∼30% of castration-resistant prostate cancer is described.
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Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6.
TL;DR: A novel mechanism for MLK3 activation by the pro-inflammatory cytokines TNF and IL-1 beta is revealed and it is suggested that K48-linked ubiquitination directs MLK 3 for proteosomal degradation while K63-linked Ubiquitination is important forMLK3 kinase activity.