Y
Yuan-Chih Chang
Researcher at Academia Sinica
Publications - 62
Citations - 1712
Yuan-Chih Chang is an academic researcher from Academia Sinica. The author has contributed to research in topics: Carbon nanotube & Homologous recombination. The author has an hindex of 17, co-authored 60 publications receiving 1230 citations. Previous affiliations of Yuan-Chih Chang include National Yunlin University of Science and Technology.
Papers
More filters
Journal ArticleDOI
Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus.
Leon Chien Wei Lin,Chen Yu Huang,Bing Yu Yao,Jung Chen Lin,Anurodh S. Agrawal,Abdullah Algaissi,Abdullah Algaissi,Bi Hung Peng,Yu Han Liu,Ping Han Huang,Rong-Huay Juang,Yuan-Chih Chang,Chien Te K. Tseng,Hui-Wen Chen,Che Ming Jack Hu +14 more
TL;DR: Together, the biocompatible hollow nanoparticle described herein provides an excellent strategy for delivering both subunit vaccine candidates and novel adjuvants, enabling accelerated development of effective and safe vaccines against emerging viral pathogens.
Journal ArticleDOI
Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation
Yi-Kai Chen,Chih-Hsiang Leng,Heidi Olivares,Ming-Hui Lee,Yuan-Chih Chang,Wen-Mei Kung,Shih-Chieh Ti,Yu-Hui Lo,Andrew H.-J. Wang,Chia-Seng Chang,Douglas K. Bishop,Yi-Ping Hsueh,Ting-Fang Wang +12 more
TL;DR: The genetic and biochemical results suggest that Hop2, Mnd1, and Dmc1 are functionally interdependent during meiotic DNA recombination.
Journal ArticleDOI
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.
Tzu-Jing Yang,Tzu-Jing Yang,Pei-Yu Yu,Yuan-Chih Chang,Kang-Hao Liang,Hsian-Cheng Tso,Meng-Ru Ho,Wan-Yu Chen,Hsiu-Ting Lin,Han-Chung Wu,Shang-Te Danny Hsu,Shang-Te Danny Hsu +11 more
TL;DR: In this paper, the spike protein of SARS-CoV-2 was analyzed in the apo and ACE2-bound forms and three RBDs were found to be engaged in ACE2 binding.
Journal ArticleDOI
Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization.
TL;DR: Vascular disruption induced by acoustic droplet vaporization can improve drug penetration more than utilizing the EPR effect, and the NDs showed longer lifetime in vivo than MDs and provided potential abilities of long periods of treatment and intertissue NDs-converted bubble cavitation to improve the drug penetration and transport distance.
Journal ArticleDOI
Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease.
Ching Hsiang Fan,Chien Yu Ting,Chung Yin Lin,Hong-Lin Chan,Yuan-Chih Chang,You Yin Chen,Hao-Li Liu,Chih-Kuang Yeh +7 more
TL;DR: It is demonstrated that the focused ultrasound-triggered GDNFp-loaded cationic microbubbles platform can achieve non-viral targeted gene delivery via a noninvasive administration route, outperform intracerebral injection in terms of targeted GDNF delivery of high-titer GDNF genes, and has a neuroprotection effect in Parkinson’s disease animal models.