Yuan-Chih Chang

TL;DR: Together, the biocompatible hollow nanoparticle described herein provides an excellent strategy for delivering both subunit vaccine candidates and novel adjuvants, enabling accelerated development of effective and safe vaccines against emerging viral pathogens.

TL;DR: The genetic and biochemical results suggest that Hop2, Mnd1, and Dmc1 are functionally interdependent during meiotic DNA recombination.

TL;DR: In this paper, the spike protein of SARS-CoV-2 was analyzed in the apo and ACE2-bound forms and three RBDs were found to be engaged in ACE2 binding.

TL;DR: Vascular disruption induced by acoustic droplet vaporization can improve drug penetration more than utilizing the EPR effect, and the NDs showed longer lifetime in vivo than MDs and provided potential abilities of long periods of treatment and intertissue NDs-converted bubble cavitation to improve the drug penetration and transport distance.

TL;DR: It is demonstrated that the focused ultrasound-triggered GDNFp-loaded cationic microbubbles platform can achieve non-viral targeted gene delivery via a noninvasive administration route, outperform intracerebral injection in terms of targeted GDNF delivery of high-titer GDNF genes, and has a neuroprotection effect in Parkinson’s disease animal models.