Yuan Soon Ho

TL;DR: The results suggest that the protective effect of LNAC may be linked to its inducement of increases in cellular GSH and bcl‐2 protein levels and to its suppression of cellular bax protein in treated cells.

TL;DR: It is demonstrated that the occurrence of apoptosis or G2/M cell cycle arrest induced by microtubule damaging agents in different cancer cells was through independent mechanisms, and activation of c-jun N-terminal kinase (JNK) signaling pathway may play an important role in the PDP-induced Bcl-2 phosphorylation and apoptosis in HL 60 cells.

TL;DR: This review summarizes the molecular mechanism(s) of various components in apple, as established in previous studies that indicated their growth-inhibitory effects in various cancer cell types and delineates the direction of future studies that could lead to the development of apple components as a potent chemopreventive/chemotherapeutic agent against cancer.

TL;DR: Elevated amounts of modified DNA bases were found in most cancerous tissues when compared to the controls, and the association of the modified bases with the processes of aging and carcinogenesis deserves further investigation.

TL;DR: Results indicate that in human pulmonary epithelial cells, IL-1β might activate phosphatidylcholine-phospholipase C through an upstream tyrosine phosphorylation to elicit PKC activation, which in turn initiates NF-κB activation, and finally induces COX-2 expression and PGE2 release.