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Yuan Soon Ho
Researcher at Taipei Medical University
Publications - 160
Citations - 7212
Yuan Soon Ho is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Apoptosis & Cancer cell. The author has an hindex of 42, co-authored 155 publications receiving 6411 citations. Previous affiliations of Yuan Soon Ho include National Taiwan University & Taipei Medical University Hospital.
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Journal ArticleDOI
Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathway.
Abdul-Fattah Salah Fararjeh,Shih Hsin Tu,Shih Hsin Tu,Li-Ching Chen,Li-Ching Chen,Tzu-chun Cheng,Yun-Ru Liu,Hang‐Lung Chang,Hui Wen Chang,Chi-Cheng Huang,Chi-Cheng Huang,Hwa-Chain Robert Wang,Wendy W. Hwang-Verslues,Chih-Hsiung Wu,Yuan Soon Ho +14 more
TL;DR: It is demonstrated that the tumorigenicity of HBL‐100, defined by soft agar colony forming, proliferation, migration and invasion abilities, was enhanced by co‐exposure to physiologically SHS achievable doses of Nic and NNK.
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p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats.
TL;DR: In this study, the mutation frequencies of the p53 gene in rat hepatocellular carcinomas induced by N‐nitroso‐2‐acetylaminofluorene and AAF were observed and the frequency and base location of p53 mutations were significantly associated with cancer cell differentiation.
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A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer.
Hui Wen Chiu,Ya Ling Yeh,Sheng Yow Ho,Yuan Hua Wu,Bour Jr Wang,Wei Jan Huang,Yuan Soon Ho,Ying Jan Wang,Li Ching Chen,Li Ching Chen,Shih Hsin Tu +10 more
TL;DR: Tumor growth in the mouse of model orthotopic breast cancer was suppressed by the combination treatment through the induction of ER stress and autophagy, which support the future evaluation of the novel HDACi TMU-35435, as a potent radiosensitizer in TNBC.
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Skin tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 mice
Wen Ching Chang,Jiiang-Huei Jeng,Chi Chang Shieh,Yi Chang Tsai,Yuan Soon Ho,How Ran Guo,Hsin I. Liu,Ching Chang Lee,Sheng Yow Ho,Ying Jan Wang +9 more
TL;DR: Evaluating whether the tumor‐promoting activity of pentachlorophenol is mainly from its major metabolite tetrachlorohydroquinone (TCHQ) showed that PCP and TCHQ are much weaker promoters than 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) in mouse skin during a 25‐wk experiment.
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Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells.
TL;DR: Abrogation of the G2 checkpoint should be an effective strategy against p53-deficient leukemia cells to irradiation-induced cell killing.