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Yuan Soon Ho
Researcher at Taipei Medical University
Publications - 160
Citations - 7212
Yuan Soon Ho is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Apoptosis & Cancer cell. The author has an hindex of 42, co-authored 155 publications receiving 6411 citations. Previous affiliations of Yuan Soon Ho include National Taiwan University & Taipei Medical University Hospital.
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Journal ArticleDOI
The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter
Kuan Hsun Wu,Chi-Tang Ho,Zhao Feng Chen,Li Ching Chen,Jacqueline Whang-Peng,Teng-Nan Lin,Yuan Soon Ho +6 more
TL;DR: In conclusion, inhibition of GLUT2 by the apple polyphenol Ph could potentially suppress TNBC tumor cell growth and metastasis.
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Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells.
Kuo Ching Yang,Chia Yi Tsai,Ying Jan Wang,Po-Li Wei,Chia-Hwa Lee,Jui Hao Chen,Chih-Hsiung Wu,Yuan Soon Ho +7 more
TL;DR: It is demonstrated that 50–150 µM Ph significantly potentiates DNA laddering induced in Hep G2 cells by 10 nM PTX, suggesting that Ph may be useful for cancer chemotherapy and chemoprevention.
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Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells.
TL;DR: Findings indicate that the above‐listed sequence of intracellular events led to the apoptosis seen in Hep G2 cells and that [Ca2+]i, Cyto c, and Fas function as intrACEllular signals to coordinate those events.
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Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells.
Chia Hwa Lee,Ya Chieh Chang,Ching Shyang Chen,Shih Hsin Tu,Ying Jan Wang,Li Ching Chen,Yu Jia Chang,Yu Jia Chang,Po Li Wei,Po Li Wei,Hui Wen Chang,Chien Hsi Chang,Ching Shui Huang,Chih Hsiung Wu,Yuan Soon Ho,Yuan Soon Ho +15 more
TL;DR: It is observed that breast tumors with higher α9-nAChR mRNA expression levels were associated with the lowest 5-year disease-specific survival rate, and in vitro promoter-binding assays demonstrated that the ER is a major transcription factor that mediates nicotine- and E2-induced up-regulation of α 9-n AChR gene expression in MCF-7 cells.
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Nicotine enhances colon cancer cell migration by induction of fibronectin
Po Li Wei,Po Li Wei,Li Jen Kuo,Li Jen Kuo,Ming Te Huang,Wen Chien Ting,Yuan Soon Ho,Weu Wang,Weu Wang,Jane An,Yu Jia Chang,Yu Jia Chang +11 more
TL;DR: Nicotine, tobacco’s additive toxin, enhances colon cancer metastasis through α7-nAChR and fibronectin—a mesenchymal marker for epithelial meschymal transition and COX-2 signal was involved in the induction of fibronECTin, suggesting smoking may play role in the progression of colon cancer.