A
Atsushi Kato
Researcher at National Institutes of Health
Publications - 4
Citations - 1768
Atsushi Kato is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA & RNase P. The author has an hindex of 4, co-authored 4 publications receiving 1627 citations.
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Journal ArticleDOI
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Mitsutoshi Yoneyama,Mika Kikuchi,Kanae Matsumoto,Tadaatsu Imaizumi,Makoto Miyagishi,Makoto Miyagishi,Kazunari Taira,Kazunari Taira,Eileen Foy,Yueh Ming Loo,Michael Gale,Shizuo Akira,Shin Yonehara,Atsushi Kato,Takashi Fujita +14 more
TL;DR: The results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors.
Journal ArticleDOI
TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA
Hiroyasu Konno,Takuya Yamamoto,Takuya Yamamoto,Kohsuke Yamazaki,Jin Gohda,Taishin Akiyama,Kentaro Semba,Hideo Goto,Atsushi Kato,Toshiaki Yujiri,Takahiko Imai,Yasushi Kawaguchi,Bing Su,Osamu Takeuchi,Shizuo Akira,Yasuko Tsunetsugu-Yokota,Jun-ichiro Inoue +16 more
TL;DR: TRAF6 mediates antiviral responses triggered by cytosolic viral DNA and RNA in a way that differs from that associated with TLR signaling, given its essential role in signaling by various receptors involved in the acquired immune system.
Journal ArticleDOI
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Tomohiko Okazaki,Maiko Higuchi,Kohsuke Takeda,Kiyoko Iwatsuki-Horimoto,Maki Kiso,Makoto Miyagishi,Hideyuki Yanai,Atsushi Kato,Mitsutoshi Yoneyama,Takashi Fujita,Tadatsugu Taniguchi,Yoshihiro Kawaoka,Hidenori Ichijo,Yukiko Gotoh +13 more
TL;DR: Results indicated that ASK1 and ASK2 are components of the antiviral defense mechanism and suggested that AsK2 acts as a key modulator that promotes apoptosis rather than the type I IFN response.
Journal ArticleDOI
Enzymatic activity necessary to restore the lethality due to Escherichia coli RNase E deficiency is distributed among bacteria lacking RNase E homologues.
TL;DR: The results suggest that Eco-RNase E-like activities might distribute among a wide array of bacteria and that functions of RNases may have changed dynamically during evolutionary divergence of bacterial lineages.