M
Mitsutoshi Yoneyama
Researcher at Chiba University
Publications - 84
Citations - 20931
Mitsutoshi Yoneyama is an academic researcher from Chiba University. The author has contributed to research in topics: Interferon & RNA. The author has an hindex of 45, co-authored 81 publications receiving 19407 citations. Previous affiliations of Mitsutoshi Yoneyama include Osaka University & Kyoto University.
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Journal ArticleDOI
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Mitsutoshi Yoneyama,Mika Kikuchi,Takashi Natsukawa,Noriaki Shinobu,Tadaatsu Imaizumi,Makoto Miyagishi,Kazunari Taira,Shizuo Akira,Takashi Fujita +8 more
TL;DR: In this article, the authors identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling.
Journal ArticleDOI
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
Journal ArticleDOI
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Mitsutoshi Yoneyama,Mika Kikuchi,Kanae Matsumoto,Tadaatsu Imaizumi,Makoto Miyagishi,Makoto Miyagishi,Kazunari Taira,Kazunari Taira,Eileen Foy,Yueh Ming Loo,Michael Gale,Shizuo Akira,Shin Yonehara,Atsushi Kato,Takashi Fujita +14 more
TL;DR: The results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors.
Journal ArticleDOI
Cell type-specific involvement of RIG-I in antiviral response
Hiroki Kato,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Tohru Tsujimura,Kiyoshi Takeda,Takashi Fujita,Osamu Takeuchi,Shizuo Akira +10 more
TL;DR: It is shown by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs) and exert antiviral responses in a cell type-specific manner.
Journal ArticleDOI
Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I
Rhea Sumpter,Yueh Ming Loo,Eileen Foy,Kui Li,Mitsutoshi Yoneyama,Takashi Fujita,Stanley M. Lemon,Michael Gale +7 more
TL;DR: It is shown that structured hepatitis C virus (HCV) genomic RNA activates interferon regulatory factor 3 (IRF3), thereby inducing Interferon in cultured cells, and RIG-I is a pathogen receptor that regulates cellular permissiveness to HCV replication and may play a key role inInterferon-based therapies for the treatment of HCV infection.