Y
Yuho Kadono
Researcher at University of Tokyo
Publications - 59
Citations - 5230
Yuho Kadono is an academic researcher from University of Tokyo. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 26, co-authored 55 publications receiving 4825 citations. Previous affiliations of Yuho Kadono include Keio University & University of Pennsylvania.
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Journal ArticleDOI
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Kojiro Sato,Ayako Suematsu,Kazuo Okamoto,Akira Yamaguchi,Yasuyuki Morishita,Yuho Kadono,Sakae Tanaka,Tatsuhiko Kodama,Shizuo Akira,Yoichiro Iwakura,Daniel J. Cua,Hiroshi Takayanagi +11 more
TL;DR: Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation and the interleukin (IL)-23–IL-17 axis, rather than the IL-12–IFN-γ axis, is critical for the onset phase of autoimmune arthritis.
Journal ArticleDOI
OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism
Matthew C. Walsh,Nacksung Kim,Yuho Kadono,Jaerang Rho,Soo Young Lee,Joseph A. Lorenzo,Yongwon Choi +6 more
TL;DR: Bone and the immune system have converged in recent years under the banner of osteo-immunology as mentioned in this paper under the name of bone and immune system, and various factors produced during immune responses are capable of profoundly affecting regulation of bone.
Osteoimmunology: Interplay Between the Immune System and Bone
Matthew C. Walsh,Nacksung Kim,Yuho Kadono,Jaerang Rho,Soo-Young Lee,Joseph A. Lorenzo,Yongwon Choi +6 more
TL;DR: Efforts are currently under way to further characterize how these two organ systems overlap and to develop therapeutic strategies that benefit from this understanding.
Journal ArticleDOI
Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis
Norihiko Kobayashi,Yuho Kadono,Yuho Kadono,Asuka Naito,Kunihiro Matsumoto,Tadashi Yamamoto,Sakae Tanaka,Jun-ichiro Inoue +7 more
TL;DR: TRAF6 plays essential roles in both the differentiation and maturation of osteoclasts by activating various kinases via its multiple domains under physiological conditions established by appropriate expression of TRAF6 mutants in TRAF 6‐deficient cells.
Journal ArticleDOI
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis.
Nacksung Kim,Yuho Kadono,Masamichi Takami,Junwon Lee,Seoung Hoon Lee,Fumihiko Okada,Jung Ha Kim,Takashi Kobayashi,Paul R. Odgren,Hiroyasu Nakano,Wen-Chen Yeh,Sun-Kyeong Lee,Joseph A. Lorenzo,Yongwon Choi +13 more
TL;DR: Surprisingly, it is shown that hematopoietic precursors from TRANCE-, RANK-, or TRAF6-null mice can become osteoclasts in vitro when they are stimulated with TNF-α in the presence of cofactors such as TGF-β.