Y
Yuichi Endo
Researcher at Fukushima Medical University
Publications - 119
Citations - 8940
Yuichi Endo is an academic researcher from Fukushima Medical University. The author has contributed to research in topics: Lectin pathway & Ficolin. The author has an hindex of 50, co-authored 119 publications receiving 8487 citations.
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Journal ArticleDOI
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria.
Junji Takeda,Toshio Miyata,Kazuyoshi Kawagoe,Yoshiyasu Iida,Yoshiyasu Iida,Yuichi Endo,Teizo Fujita,Minoru Takahashi,Teruo Kitani,Taroh Kinoshita +9 more
TL;DR: It is reported that PIG-A, which participates in the early step of GPI anchor biosynthesis, is the gene responsible for paroxysmal nocturnal hemoglobinuria.
Journal ArticleDOI
The lectin‐complement pathway – its role in innate immunity and evolution
TL;DR: It seems likely that the complement system played a pivotal role in innate immunity before the evolution of an acquired immune system in jawed vertebrates.
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Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes.
Akira Shibuya,Norihisa Sakamoto,Norihisa Sakamoto,Yoshio Shimizu,Kazuko Shibuya,Kazuko Shibuya,Mitsujiro Osawa,Takashi Hiroyama,Helen J. Eyre,Grant R. Sutherland,Yuichi Endo,Teizo Fujita,Tomoyuki Miyabayashi,Seiji Sakano,Takao Tsuji,Eiichi Nakayama,Joseph H. Phillips,Lewis L. Lanier,Hiromitsu Nakauchi +18 more
TL;DR: A mouse Fc receptor, designated Fcα/μR, and its human homolog, that bind both IgM and IgA with intermediate or high affinity are described that are involved in the primary stages of the immune response to microbes.
Journal ArticleDOI
A Novel Human Serum Lectin with Collagen- and Fibrinogen-like Domains That Functions as an Opsonin
Misao Matsushita,Yuichi Endo,Satoshi Taira,Yasuo Sato,Teizo Fujita,Narumi Ichikawa,Munehiro Nakata,Tsuguo Mizuochi +7 more
TL;DR: A novel Ca2+-dependent and GlcNAc-binding lectin consisting of subunits of 35 kDa (P35) with a collagen-like sequence is reported, which represents a new type of Glc NAc- binding lectin with structural and functional similarities to collectins involved in innate immunity.
Journal ArticleDOI
Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.
TL;DR: Ficolin/P35, a human serum ficolin, was found to copurify with MASPs and sMAP, a second collagenous lectin capable of activating the lecturer pathway and thus plays a role in innate immunity.