Yuji Miyahara

TL;DR: In this article, a silicon chip with an open-tubular column and a conductometric detector, a chip holder and a pressure pulse driven injector using a conventional liquid chromatography pump and valves is presented, which has theoretical separation efficiencies of 8000 and 25 000 plates in 1 and 5 min, respectively.

TL;DR: Developed PBA-installed micellar nanocarriers incorporating the parent complex of the anticancer drug oxaliplatin for targeting sialylated epitopes overexpressed on cancer cells, which effectively reduced the growth rate of both orthotopic and lung metastasis models of melanoma.

TL;DR: PBA, a synthetic molecule capable of reversibly binding with 1,2or 1,3-cis-diols including glucose, is utilized as the molecular basis and systemically explored the structure–property correlation by focusing on (meth)acrylamide-based hydrogels.

TL;DR: It is demonstrated that the PBA-assisted PIC micelles can be tailored to exhibit a dramatic disruption accompanied by the release of siRNAs in response to a change in the ribose concentration (which parallels events in the intracellular environment).

TL;DR: A potentiometric SA detection using a phenylboronic acid compound integrated into the form of a self-assembled monolayer (SAM) onto a field effect transistor (FET) extended gold gate electrode is developed, revealing that the disease could be feasibly diagnosed simply by placing the known-count cell suspensions onto the device without any labeling and enzymatic procedures.