Horacio Cabral

TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.

TL;DR: By shaping these features, polymeric micelles have been propitious for delivering a wide range of therapeutics through effective sensing of targets in the body and adjustment of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level.

TL;DR: This review summarizes recent efforts in the development of self-assemblies of amphiphilic block copolymers consisting of a hydrophobic core as a drug reservoir and a poly(ethylene glycol) (PEG) hydrophilic shell as tumor-targeted nanocarriers with high translational potential and their performance in human studies.

TL;DR: CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors, according to the passive targeting manner, and its utility as a tumor-targeted drug delivery system was investigated.

TL;DR: A compilation of commentaries gives a historical perspective and current status of research covered in some of the most cited research articles in the history of the Journal of Controlled Release.