Mitsuru Naito

TL;DR: It is found that Notch1 activation in GSCs specifically induces expression of the lncRNA, TUG1, which highlights the importance of the Notch-lncRNA axis in regulating self-renewal of glioma cells and provides a strong rationale for targeting Tug1 as a specific and potent therapeutic approach to eliminate the GSC population.

TL;DR: It is demonstrated that the PBA-assisted PIC micelles can be tailored to exhibit a dramatic disruption accompanied by the release of siRNAs in response to a change in the ribose concentration (which parallels events in the intracellular environment).

TL;DR: Systemically administered cRGD/Chol-siRNA micelles exhibited significant gene silencing activity in the tumor, presumably due to their active targeting ability combined with the enhanced stability through both hydrophobic interactions of cholesterol and disulfide cross-linking.

TL;DR: Glucose‐coated polymeric nanocarriers enable noninvasive ASO administration to the brain for the treatment of CNS disorders and exhibits significant knockdown of a target long non‐coding RNA in various brain regions, including the cerebral cortex and hippocampus.

TL;DR: This research demonstrates that the bottom-up construction of nanocarriers using monodispersed building blocks can be employed as delivery platforms for RNA interference-based cancer therapy.