W
Weiqun Peng
Researcher at George Washington University
Publications - 78
Citations - 11666
Weiqun Peng is an academic researcher from George Washington University. The author has contributed to research in topics: Cellular differentiation & Chromatin. The author has an hindex of 33, co-authored 67 publications receiving 10190 citations. Previous affiliations of Weiqun Peng include Florida State University College of Arts and Sciences & University of Illinois at Urbana–Champaign.
Papers
More filters
Journal ArticleDOI
Combinatorial patterns of histone acetylations and methylations in the human genome
Zhibin Wang,Chongzhi Zang,Jeffrey A. Rosenfeld,Jeffrey A. Rosenfeld,Dustin E. Schones,Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Weiqun Peng,Michael Q. Zhang,Keji Zhao +11 more
TL;DR: The data suggest that a large number of histone modifications may act cooperatively to prepare chromatin for transcriptional activation and be associated with promoters and enhancers.
Journal ArticleDOI
Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes
TL;DR: In this paper, a genome-wide mapping of HATs and deacetylases binding on chromatin was performed and it was found that both are found at active genes with acetylated histones.
Journal ArticleDOI
Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells
Gang Wei,Lai Wei,Jinfang Zhu,Chongzhi Zang,Jane Hu-Li,Zhengju Yao,Kairong Cui,Yuka Kanno,Tae-Young Roh,Wendy T. Watford,Dustin E. Schones,Weiqun Peng,Hong-Wei Sun,William E. Paul,John J. O'Shea,Keji Zhao +15 more
TL;DR: Although modifications of signature-cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, genes encoding transcription factors like Tbx21 exhibit a broad spectrum of epigenetic states, consistent with the demonstrated T-bet and interferon-gamma induction in nTreg cells.
Journal ArticleDOI
A clustering approach for identification of enriched domains from histone modification ChIP-Seq data
TL;DR: Based on the biological observation that histone modifications tend to cluster to form domains, a method that identifies spatial clusters of signals unlikely to appear by chance is presented that outperforms existing methods in the identification of ChIP-enriched signals for histone modification profiles.
Journal ArticleDOI
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.
TL;DR: It is shown that preparative methods used previously in studying nucleosome structure result in the loss of these unstable double-variant NCPs, and it seems likely that this instability facilitates the access of transcription factors to promoters and other regulatory sites in vivo.