Y
Yul W. Yang
Researcher at Mayo Clinic
Publications - 25
Citations - 2707
Yul W. Yang is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Gene expression. The author has an hindex of 8, co-authored 19 publications receiving 2434 citations. Previous affiliations of Yul W. Yang include Stanford University & Yale University.
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Journal ArticleDOI
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Kevin C. Wang,Yul W. Yang,Bo Liu,Amartya Sanyal,Ryan Corces-Zimmerman,Yong Chen,Bryan R. Lajoie,Angeline Protacio,Ryan A. Flynn,Rajnish A. Gupta,Joanna Wysocka,Ming Lei,Job Dekker,Jill A. Helms,Howard Y. Chang +14 more
TL;DR: OTTIP RNA binds the adaptor protein WDR5 directly and targets WDR 5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.
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The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.
J. Antonio Gomez,Orly L. Wapinski,Yul W. Yang,Jean-François Bureau,Smita Gopinath,Denise M. Monack,Howard Y. Chang,Michel Brahic,Karla Kirkegaard +8 more
TL;DR: An enhancer-like lncRNA termed NeST is shown to be causal for all phenotypes conferred by murine viral susceptibility locus Tmevp3, and regulates epigenetic marking of IFN-γ-encoding chromatin, expression of IFn-γ, and susceptibility to a viral and a bacterial pathogen.
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Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency
Yul W. Yang,Ryan A. Flynn,Yong Chen,Kun Qu,Bingbing Wan,Kevin C. Wang,Ming Lei,Howard Y. Chang +7 more
TL;DR: It is suggested that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates.
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LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes.
Hanqian L. Carlson,Jeffrey J. Quinn,Yul W. Yang,Chelsea K. Thornburg,Howard Y. Chang,H. Scott Stadler,H. Scott Stadler +6 more
TL;DR: Findings reveal a fundamental epigenetic mechanism functioning during early limb development, using LncRNA-HIT and its associated proteins to promote the expression of multiple genes whose products are necessary for the formation of cartilage.
Journal ArticleDOI
Virus population extinction via ecological traps.
TL;DR: It is demonstrated that viruses can sustain high rates of population growth in the presence of neutral non-hosts as long as some host cells are present, whereas trap cells dramatically reduce viral fitness.