B
Bo Liu
Researcher at Peking University
Publications - 49
Citations - 4116
Bo Liu is an academic researcher from Peking University. The author has contributed to research in topics: Wnt signaling pathway & Stem cell. The author has an hindex of 23, co-authored 46 publications receiving 3627 citations. Previous affiliations of Bo Liu include University of Rochester & Stanford University.
Papers
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Journal ArticleDOI
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Kevin C. Wang,Yul W. Yang,Bo Liu,Amartya Sanyal,Ryan Corces-Zimmerman,Yong Chen,Bryan R. Lajoie,Angeline Protacio,Ryan A. Flynn,Rajnish A. Gupta,Joanna Wysocka,Ming Lei,Job Dekker,Jill A. Helms,Howard Y. Chang +14 more
TL;DR: OTTIP RNA binds the adaptor protein WDR5 directly and targets WDR 5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.
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The role of Axin2 in calvarial morphogenesis and craniosynostosis
Hsiao-Man Ivy Yu,Boris Jerchow,Tzong-Jen Sheu,Bo Liu,Frank Costantini,J. Edward Puzas,Walter Birchmeier,Wei Hsu +7 more
TL;DR: The data argue for a region-specific effect of Axin2 on neural crest dependent skeletogenesis as the mammalian skull is formed from cranial skeletogenic mesenchyme, which is derived from mesoderm and neural crest, and for a novel role for the Wnt pathway in skull morphogenesis.
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Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
Lingjie Li,Bo Liu,Orly L. Wapinski,Miao-Chih Tsai,Kun Qu,Jiajing Zhang,Jeffrey C. Carlson,Meihong Lin,Fengqin Fang,Rajnish A. Gupta,Jill A. Helms,Howard Y. Chang +11 more
TL;DR: It is shown that targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones.
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Differentiation of multipotent vascular stem cells contributes to vascular diseases
Zhenyu Tang,Aijun Wang,Aijun Wang,Falei Yuan,Zhiqiang Yan,Bo Liu,Julia S. Chu,Jill A. Helms,Song Li +8 more
TL;DR: Evidence is provided that the differentiation of MVSCs, rather than the de-differentiation of SMCs, contributes to vascular remodeling and diseases, and this hypothesis is supported.
Journal ArticleDOI
Wnt Proteins Promote Bone Regeneration
Steven Minear,Philipp Leucht,Jie Jiang,Bo Liu,Arial Zeng,Christophe Fuerer,Roel Nusse,Jill A. Helms +7 more
TL;DR: The authors used genetically altered mice to show that Wnt signaling is increased in regions in which bone is healing, which suggests that it participates in the bone regeneration process, and devised a biochemical strategy to increase the duration and strength of Wnt signalling at the sites of skeletal injury.