C
Cristina Legido-Quigley
Researcher at Steno Diabetes Center
Publications - 166
Citations - 5521
Cristina Legido-Quigley is an academic researcher from Steno Diabetes Center. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 32, co-authored 140 publications receiving 3975 citations. Previous affiliations of Cristina Legido-Quigley include Imperial College London & University of Pavia.
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Journal ArticleDOI
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
François-Pierre Martin,François-Pierre Martin,Marc-Emmanuel Dumas,Yulan Wang,Cristina Legido-Quigley,Ivan K. S. Yap,Huiru Tang,Severine Zirah,Gerard M. Murphy,Olivier Cloarec,John C. Lindon,Norbert Sprenger,Laurent B. Fay,Sunil Kochhar,Peter J. van Bladeren,Elaine Holmes,Jeremy K. Nicholson +16 more
TL;DR: Data indicate that the microbiome modulates absorption, storage and the energy harvest from the diet at the systems level, impacting directly on the host's ability to metabolize lipids.
Journal ArticleDOI
Metabolic network failures in Alzheimer's disease: A biochemical road map
Jon B. Toledo,Jon B. Toledo,Matthias Arnold,Gabi Kastenmüller,Rui Chang,Rebecca Baillie,Xianlin Han,Madhav Thambisetty,Jessica D. Tenenbaum,Karsten Suhre,J. Will Thompson,Lisa St. John-Williams,Siamak Mahmoudiandehkordi,Daniel M. Rotroff,John Jack,Alison A. Motsinger-Reif,Shannon L. Risacher,Colette Blach,Joseph E. Lucas,Tyler Massaro,Gregory Louie,Hongjie Zhu,Guido Dallmann,Kristaps Klavins,Therese Koal,Sungeun Kim,Kwangsik Nho,Li Shen,Ramon Casanova,Sudhir Varma,Cristina Legido-Quigley,M. Arthur Moseley,Kuixi Zhu,Marc Henrion,Sven J. van der Lee,Amy C. Harms,Ayse Demirkan,Thomas Hankemeier,Thomas Hankemeier,Cornelia M. van Duijn,Cornelia M. van Duijn,John Q. Trojanowski,Leslie M. Shaw,Andrew J. Saykin,Michael W. Weiner,P. Murali Doraiswamy,Rima Kaddurah-Daouk +46 more
TL;DR: This article used metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance.
Journal ArticleDOI
Evidence for brain glucose dysregulation in Alzheimer's disease
Yang An,Vijay R. Varma,Sudhir Varma,Ramon Casanova,Eric B. Dammer,Olga Pletnikova,Chee W. Chia,Josephine M. Egan,Luigi Ferrucci,Juan C. Troncoso,Allan I. Levey,James J. Lah,Nicholas T. Seyfried,Cristina Legido-Quigley,Richard O'Brien,Madhav Thambisetty +15 more
TL;DR: It is unclear whether abnormalities in brain glucose homeostasis are associated with Alzheimer's disease (AD) pathogenesis, but efforts are being made to find out.
Journal ArticleDOI
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Vijay R. Varma,Anup M. Oommen,Sudhir Varma,Ramon Casanova,Yang An,Ryan M. Andrews,Richard O'Brien,Olga Pletnikova,Juan C. Troncoso,Jon B. Toledo,Rebecca Baillie,Matthias Arnold,Gabi Kastenmueller,Kwangsik Nho,P. Murali Doraiswamy,Andrew J. Saykin,Rima Kaddurah-Daouk,Cristina Legido-Quigley,Madhav Thambisetty +18 more
TL;DR: Different sphingolipid species identified map to several biologically relevant pathways implicated in AD, including tau phosphorylation, amyloid-β (Aβ) metabolism, calcium homeostasis, acetylcholine biosynthesis, and apoptosis.
Journal ArticleDOI
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
Luke Whiley,Arundhuti Sen,James Heaton,Petroula Proitsi,Diego García-Gómez,Rufina Leung,Norman W. Smith,Madhav Thambisetty,Iwona Kłoszewska,Patrizia Mecocci,Hilkka Soininen,Magda Tsolaki,Bruno Vellas,Simon Lovestone,Cristina Legido-Quigley +14 more
TL;DR: Confirmatory investigations into the background biochemistry indiciated no significant change in plasma levels of 3 additional PCs of similar structure, total choline containing compounds or total plasma omega fatty acids, adding to the evidence that specific PCs play a role in AD pathology.