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Yusei Ohshima
Researcher at University of Fukui
Publications - 141
Citations - 3762
Yusei Ohshima is an academic researcher from University of Fukui. The author has contributed to research in topics: CD28 & Cytotoxic T cell. The author has an hindex of 30, co-authored 131 publications receiving 3397 citations. Previous affiliations of Yusei Ohshima include Université de Montréal & Japan Agency for Medical Research and Development.
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Journal Article
Expression and function of OX40 ligand on human dendritic cells.
TL;DR: The expression of OX40L on DC suggests a physiologic role of this molecule during T cell priming by virtue of its ability to costimulate both T cell and DC activation and differentiation.
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OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.
Yusei Ohshima,Liang Peng Yang,Takashki Uchiyama,Yuetsu Tanaka,Peter R. Baum,Martin Sergerie,Patrice Hermann,Guy Delespesse +7 more
TL;DR: It is shown that ligation of OX40 Ag, a member of the tumor necrosis factor receptor (TNF-R) family, on activated umbilical cord blood CD4+ T cells upregulates IL-4 production at priming and thereby promotes their development into effector cells producing high levels of the type 2 cytokines IL- 4, IL-5, and IL-13.
Journal Article
Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.
Kenji Katamura,Noriaki Shintaku,Y Yamauchi,Tetsuya Fukui,Yusei Ohshima,Mitsufumi Mayumi,Kenshi Furusho +6 more
TL;DR: PGE2 must exist at an early stage of T cell activation to inhibit priming for IL-2 and IFN-gamma production, and it is suggested that PGE2 plays a role in facilitating the development of the Th2-type cytokine production profile.
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Aicardi-Goutières syndrome is caused by IFIH1 mutations.
Hirotsugu Oda,Kenji Nakagawa,Junya Abe,Tomonari Awaya,Masahide Funabiki,Atsushi Hijikata,Ryuta Nishikomori,Makoto Funatsuka,Yusei Ohshima,Yuji Sugawara,Takahiro Yasumi,Hiroki Kato,Tsuyoshi Shirai,Osamu Ohara,Takashi Fujita,Toshio Heike +15 more
TL;DR: This study suggests that the IFIH1 mutations are responsible for the AGS phenotype due to an excessive production of type I interferon.
Journal ArticleDOI
Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis.
Hirokazu Tsukahara,Rumiko Shibata,Yusei Ohshima,Yukiko Todoroki,Shuko Sato,Naoko Ohta,Masahiro Hiraoka,Akira Yoshida,Sankei Nishima,Mitsufumi Mayumi +9 more
TL;DR: The findings indicate that oxidative stress and altered antioxidant defenses are involved in the pathophysiology of acute exacerbation of AD, and that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.