Z
Z. Hong Zhou
Researcher at University of California, Los Angeles
Publications - 251
Citations - 13342
Z. Hong Zhou is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Capsid & Biology. The author has an hindex of 58, co-authored 225 publications receiving 11143 citations. Previous affiliations of Z. Hong Zhou include University of Texas Health Science Center at Houston & University of Science and Technology of China.
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Journal ArticleDOI
Symmetry-adapted spherical harmonics method for high-resolution 3D single-particle reconstructions
TL;DR: This work has implemented a new algorithm for reconstructing 3D structures of macromolecular complexes with icosahedral symmetry from cryoEM images using Icosahedral symmetry-adapted functions to interpolate structural factors in the reciprocal space to generate a 3D reconstruction in spherical coordinates.
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Direct Visualization of the Putative Portal in the Kaposi's Sarcoma-Associated Herpesvirus Capsid by Cryoelectron Tomography
TL;DR: This report reports the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus.
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Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication.
TL;DR: A proof-of-concept demonstration of the use of polypeptides that mimic the smallest capsid protein to inhibit KSHV lytic replication highlights the potential for exploiting the interaction hotspots revealed in the atomic structure to develop antiviral agents.
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De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes.
Kalli Kappel,Shiheng Liu,Kevin P. Larsen,Georgios Skiniotis,Elisabetta Viani Puglisi,Joseph D. Puglisi,Z. Hong Zhou,Rui Zhao,Rhiju Das +8 more
TL;DR: DRRAFTER, a method for RNA modeling into cryo-EM maps, generates accurate models for diverse RNA–protein complexes and is applied to recently determined maps of telomerase, the HIV-1 reverse transcriptase initiation complex, and the packaged MS2 genome, demonstrating the acceleration of accurate model building in challenging cases.
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DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV.
Danyang Gong,Xinghong Dai,Jonathan Jih,Yun-Tao Liu,Yun-Tao Liu,Guo-Qiang Bi,Ren Sun,Z. Hong Zhou +7 more
TL;DR: Structural-based mutageneses confirm that a triplex deep binding groove for CATCs is a hotspot that holds promise for antiviral development and suggests a mechanism whereby the portal orchestrates procapsid formation and asymmetric long-range determination of CATC attachment during DNA packaging prior to pleomorphic tegumentation/envelopment.